Adenosine receptor A2a
Also known as: ADORA2, ADORA2A
Function
Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Adeno_A2A_rcpt, Adenosn_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 96
- 2YDO X-ray 3.00A
- 2YDV X-ray 2.60A
- 3EML X-ray 2.60A
- 3PWH X-ray 3.30A
- 3QAK X-ray 2.71A
- 3REY X-ray 3.31A
- 3RFM X-ray 3.60A
- 3UZA X-ray 3.27A
- 3UZC X-ray 3.34A
- 3VG9 X-ray 2.70A
- 3VGA X-ray 3.10A
- 4EIY X-ray 1.80A
- … and 84 more
A predicted model is available from AlphaFold.
Gene Ontology · 62
- GO:0032279 asymmetric synapse
- GO:0030673 axolemma
- GO:0030425 dendrite
- GO:0098978 glutamatergic synapse
- GO:0005882 intermediate filament
- GO:0016020 membrane
- GO:0043025 neuronal cell body
- GO:0005886 plasma membrane
- GO:0045211 postsynaptic membrane
- GO:0048786 presynaptic active zone
- GO:0042734 presynaptic membrane
- GO:0051393 alpha-actinin binding
- GO:0005516 calmodulin binding
- GO:0019899 enzyme binding
- GO:0001609 G protein-coupled adenosine receptor activity
- GO:0042802 identical protein binding
- GO:0008289 lipid binding
- GO:0044877 protein-containing complex binding
- GO:0031802 type 5 metabotropic glutamate receptor binding
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- GO:0006915 apoptotic process
- GO:0048143 astrocyte activation
- GO:0008015 blood circulation
- GO:0007596 blood coagulation
- GO:0007267 cell-cell signaling
- GO:0006968 cellular defense response
- GO:0007417 central nervous system development
- GO:0042755 eating behavior
- GO:0060079 excitatory postsynaptic potential
- GO:0001973 G protein-coupled adenosine receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0007626 locomotory behavior
- GO:0051899 membrane depolarization
- GO:0008285 negative regulation of cell population proliferation
- GO:0043524 negative regulation of neuron apoptotic process
- GO:0043116 negative regulation of vascular permeability
- GO:0048812 neuron projection morphogenesis
- GO:0006909 phagocytosis
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0014057 positive regulation of acetylcholine secretion, neurotransmission
- GO:0045938 positive regulation of circadian sleep/wake cycle, sleep
- GO:0070374 positive regulation of ERK1 and ERK2 cascade
- GO:0014049 positive regulation of glutamate secretion
- GO:1900273 positive regulation of long-term synaptic potentiation
- GO:0050714 positive regulation of protein secretion
- GO:0051968 positive regulation of synaptic transmission, glutamatergic
- GO:0035810 positive regulation of urine volume
- GO:0060134 prepulse inhibition
- GO:0099171 presynaptic modulation of chemical synaptic transmission
- GO:0051924 regulation of calcium ion transport
- GO:0006355 regulation of DNA-templated transcription
- GO:0051881 regulation of mitochondrial membrane potential
- GO:0014061 regulation of norepinephrine secretion
- GO:0031000 response to caffeine
- GO:0014074 response to purine-containing compound
- GO:0009410 response to xenobiotic stimulus
- GO:0007600 sensory perception
- GO:0007271 synaptic transmission, cholinergic
- GO:0001963 synaptic transmission, dopaminergic
- GO:0035249 synaptic transmission, glutamatergic
- GO:0042311 vasodilation
Drugs targeting this protein · 27
- UK432097 agonist
- CAFFEINE antagonist
- OXTRIPHYLLINE antagonist
- CAFFEINE CITRATE antagonist
- THEOPHYLLINE SODIUM GLYCINATE antagonist
- THEOPHYLLINE antagonist
- AMINOPHYLLINE antagonist
- SONEDENOSON agonist
- BINODENOSON agonist
- APADENOSON agonist
- EVODENOSON agonist
- ST1535 antagonist
- TOZADENANT antagonist
- PRELADENANT antagonist
- AMP579 agonist
- PBF-509 antagonist
- PBF-999 antagonist
- REGADENOSON agonist
- CIFORADENANT antagonist
- ISTRADEFYLLINE antagonist
- VIPADENANT antagonist
- IMARADENANT antagonist
- BVT.115959 agonist
- ETRUMADENANT antagonist
- ADENOSINE agonist
- SIPAGLADENANT inverse agonist
- PENTOXIFYLLINE antagonist
Related proteins · sequence + function similarity
- Adenosine receptor A2a 0.99
- Adenosine receptor A2a 0.99
- Adenosine receptor A2a 0.98
- Adenosine receptor A2a 0.97
- Adenosine receptor A2a 0.97
- Adenosine receptor A2b 0.92
- Adenosine receptor A2b 0.92
- Adenosine receptor A2b 0.91
- Adenosine receptor A2b 0.91
- Adenosine receptor A2b 0.91
- Adenosine receptor A2b 0.89
- Beta-4C adrenergic receptor 0.86
Co-cited proteins · studied together in the literature
- D(4) dopamine receptor 1 shared papers
- Ubiquitin carboxyl-terminal hydrolase 4 1 shared papers
- N-terminal EF-hand calcium-binding protein 2 1 shared papers
- N-terminal EF-hand calcium-binding protein 2 1 shared papers
- Adenosine receptor A2a 1 shared papers
- Ubiquitin carboxyl-terminal hydrolase 4 1 shared papers
Literature · 12 cited papers
- Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature · 2011
- The dopamine D(4) receptor, the ultimate disordered protein. J. Recept. Signal Transduct. · 2010
- The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science · 2008
- The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Mol. Cell. Neurosci. · 2007
- The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Mol. Pharmacol. · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
- Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A. Biochem. Biophys. Res. Commun. · 1996
- Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. J. Biol. Chem. · 1995
- Molecular characterization of a human brain adenosine A2 receptor. Brain Res. Mol. Brain Res. · 1992
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.