Penicillin-binding protein 1A

Function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Classification

Family (Pfam)

PF17092 PCB_OB, PF00912 Transgly, PF00905 Transpeptidase

InterPro

Beta-lactam/transpept-like, Glyco_trans_51, Glycosyltr_51/Transpeptidase, Lysozyme-like_dom_sf, PBP_transglycosylase, PCB_OB, PCN-bd_Tpept

Functional cluster

Membrane Insertases & Cytochromes

Gene Ontology · 10

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0005886 plasma membrane
• GO:0008658 penicillin binding
• GO:0008955 peptidoglycan glycosyltransferase activity
• GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
• GO:0071555 cell wall organization
• GO:0009252 peptidoglycan biosynthetic process
• GO:0006508 proteolysis
• GO:0008360 regulation of cell shape
• GO:0046677 response to antibiotic

Drugs targeting this protein · 85

• CEFOTAXIME SODIUM inhibitor
• AMOXICILLIN inhibitor
• CEFUROXIME AXETIL inhibitor
• PENICILLIN G SODIUM inhibitor
• CEFAMANDOLE inhibitor
• CYCLACILLIN inhibitor
• MOXALACTAM DISODIUM inhibitor
• CEPHALEXIN HYDROCHLORIDE inhibitor
• CEFOPERAZONE SODIUM inhibitor
• CEFAZOLIN SODIUM inhibitor
• CEFOXITIN SODIUM inhibitor
• CEPHALEXIN inhibitor
• LORACARBEF inhibitor
• CEFPIRAMIDE SODIUM inhibitor
• AMPICILLIN SODIUM inhibitor
• CEFTAZIDIME SODIUM inhibitor
• PIPERACILLIN SODIUM inhibitor
• PENICILLIN V POTASSIUM inhibitor
• TICARCILLIN DISODIUM inhibitor
• CEFEPIME HYDROCHLORIDE inhibitor
• BACAMPICILLIN HYDROCHLORIDE inhibitor
• CEPHALOGLYCIN inhibitor
• CEFTIBUTEN DIHYDRATE inhibitor
• CARBENICILLIN INDANYL SODIUM inhibitor
• CEFONICID SODIUM inhibitor
• CEFPODOXIME PROXETIL inhibitor
• CEFACLOR inhibitor
• CEFTIZOXIME SODIUM inhibitor
• CEPHAPIRIN SODIUM inhibitor
• CEFORANIDE inhibitor
• CEFOTETAN DISODIUM inhibitor
• CEFMETAZOLE SODIUM inhibitor
• CEFTOLOZANE SULFATE inhibitor
• PENICILLIN G POTASSIUM inhibitor
• ERTAPENEM SODIUM inhibitor
• RAZUPENEM inhibitor
• FAROPENEM MEDOXOMIL inhibitor
• MEROPENEM inhibitor
• TEMOCILLIN inhibitor
• ERTAPENEM inhibitor
• CEFIXIME inhibitor
• FLOMOXEF inhibitor
• AZTREONAM inhibitor
• CEPHRADINE inhibitor
• CEFTIBUTEN inhibitor
• PHENETHICILLIN inhibitor
• CEFAMANDOLE NAFATE inhibitor
• TALAMPICILLIN inhibitor
• CEPHALOTHIN SODIUM inhibitor
• CEFADROXIL inhibitor
• CEFPODOXIME inhibitor
• MEZLOCILLIN SODIUM inhibitor
• AMPICILLIN inhibitor
• SULOPENEM inhibitor
• PENAMECILLIN inhibitor
• TEBIPENEM PIVOXIL inhibitor
• CEFUROXIME SODIUM inhibitor
• FLOXACILLIN inhibitor
• CEFTIOFUR inhibitor
• CEFODIZIME inhibitor
• PIVAMPICILLIN inhibitor
• CEFMENOXIME HYDROCHLORIDE inhibitor
• CEFSULODIN inhibitor
• CEFTAROLINE FOSAMIL ACETATE inhibitor
• AZTREONAM LYSINE inhibitor
• PENICILLIN G BENZATHINE inhibitor
• CEFIDEROCOL inhibitor
• CEFIDEROCOL SULFATE TOSYLATE inhibitor
• CEFILAVANCIN inhibitor
• CEFOTIAM HYDROCHLORIDE inhibitor
• DORIPENEM MONOHYDRATE inhibitor
• IMIPENEM inhibitor
• CEFTAZIDIME inhibitor
• CEFDITOREN PIVOXIL inhibitor
• SULOPENEM ETZADROXIL inhibitor
• DORIPENEM inhibitor
• CEFTAROLINE FOSAMIL inhibitor
• CEFTOBIPROLE inhibitor
• CEFPROZIL, (E)- inhibitor
• FAROPENEM inhibitor
• CARBENICILLIN DISODIUM inhibitor
• CEFTRIAXONE SODIUM inhibitor
• PENICILLIN V inhibitor
• CEFPIROME inhibitor
• CEFDINIR inhibitor

Related proteins · sequence + function similarity

• Penicillin-binding protein 1A 0.94
• Penicillin-binding protein 1A 0.93
• Penicillin-binding protein 1A 0.92
• Penicillin-binding protein 1A 0.90
• Penicillin-binding protein 1A 0.88
• Penicillin-binding protein 1A 0.87
• Penicillin-binding protein 1A 0.86
• Penicillin-binding protein 1A 0.86
• Penicillin-binding protein 1A 0.86
• Penicillin-binding protein 1A 0.85
• Penicillin-binding protein 1A 0.85
• Penicillin-binding protein 1B 0.85

Co-cited proteins · studied together in the literature

• Penicillin-binding protein 1B 3 shared papers
• Penicillin-binding protein 1C 1 shared papers

Literature · 6 cited papers

• Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
• Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Microbiol. Mol. Biol. Rev. · 1998
• The complete genome sequence of Escherichia coli K-12. Science · 1997
• Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A. Biochem. Biophys. Res. Commun. · 1980
• Sequences of the active-site peptides of three of the high-Mr penicillin-binding proteins of Escherichia coli K-12. Proc. Natl. Acad. Sci. U.S.A. · 1985
• The nucleotide sequences of the ponA and ponB genes encoding penicillin-binding protein 1A and 1B of Escherichia coli K12. Eur. J. Biochem. · 1985