Penicillin-binding protein 1A
Also known as: PA5045, mrcA, ponA
Function
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Classification
- Family (Pfam)
- PF17092 PCB_OB, PF00912 Transgly, PF00905 Transpeptidase
- InterPro
- Beta-lactam/transpept-like, Glyco_trans_51, Glycosyltr_51/Transpeptidase, Lysozyme-like_dom_sf, PBP_transglycosylase, PCB_OB, PCN-bd_Tpept
- Functional cluster
- Membrane Insertases & Cytochromes
Experimental structures · PDB · 1
- 4OON X-ray 3.20A
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0030288 outer membrane-bounded periplasmic space
- GO:0005886 plasma membrane
- GO:0008658 penicillin binding
- GO:0008955 peptidoglycan glycosyltransferase activity
- GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
- GO:0071555 cell wall organization
- GO:0009252 peptidoglycan biosynthetic process
- GO:0006508 proteolysis
- GO:0008360 regulation of cell shape
- GO:0046677 response to antibiotic
Drugs targeting this protein · 1
- AZLOCILLIN SODIUM inhibitor
Related proteins · sequence + function similarity
- Penicillin-binding protein 1A 0.93
- Penicillin-binding protein 1A 0.93
- Penicillin-binding protein 1A 0.92
- Penicillin-binding protein 1A 0.91
- Penicillin-binding protein 1A 0.91
- Penicillin-binding protein 1A 0.90
- Penicillin-binding protein 1A 0.90
- Penicillin-binding protein 1A 0.89
- Penicillin-binding protein 1A 0.89
- Penicillin-binding protein 1A 0.89
- Penicillin-binding protein 1A 0.89
- Penicillin-binding protein 1A 0.88
Co-cited proteins · studied together in the literature
- Shikimate kinase 1 shared papers
- 3-dehydroquinate synthase 1 shared papers
- Fimbrial assembly protein PilQ 1 shared papers
- DNA utilization protein HofQ 1 shared papers
Literature · 2 cited papers
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