Serine/threonine-protein kinase D3

Function

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Classification

Family (Pfam)

PF00130 C1_1, PF00169 PH, PF00069 Pkinase, PF25525 Ubiquitin_PRKD1_N

InterPro

C1-like_sf, DAG/PE-bd, Kinase-like_dom_sf, PH-like_dom_sf, PH_domain, PKC_DAG/PE, Prot_kinase_dom, Protein_kinase_ATP_BS, Protein_Kinase_C_mu-related, Ser/Thr_kinase_AS, Ubiquitin_PRKD1-3_N

Functional cluster

Protein Serine/Threonine Kinases

Experimental structures · PDB · 1

• 2D9Z NMR

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0005524 ATP binding
• GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
• GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
• GO:0016301 kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0008270 zinc ion binding
• GO:0035556 intracellular signal transduction
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
• GO:0006468 protein phosphorylation
• GO:0030148 sphingolipid biosynthetic process

Drugs targeting this protein · 5

• GSK-690693 inhibitor
• SOTRASTAURIN inhibitor
• UCN-01 inhibitor
• CEP-2563 DIHYDROCHLORIDE inhibitor
• MIDOSTAURIN inhibitor

Related proteins · sequence + function similarity

• Serine/threonine-protein kinase D3 0.99
• Serine/threonine-protein kinase D1 0.96
• Serine/threonine-protein kinase D1 0.96
• Serine/threonine-protein kinase D1 0.95
• Serine/threonine-protein kinase D2 0.86
• Serine/threonine-protein kinase D2 0.85
• Serine/threonine-protein kinase D2 0.85
• Serine/threonine-protein kinase N2 0.76
• Serine/threonine-protein kinase N2 0.75
• Serine/threonine-protein kinase N2 0.75
• Serine/threonine-protein kinase N2 0.73
• Serine/threonine-protein kinase dkf-2 0.73

Co-cited proteins · studied together in the literature

• Serine/threonine-protein kinase D2 1 shared papers
• Serine/threonine-protein kinase D1 1 shared papers

Literature · 12 cited papers

• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family. Biochem. J. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. · 2006
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu. Biochim. Biophys. Acta · 1999