lmmol · Proteins

Protein mono-ADP-ribosyltransferase PARP3

UniProt Q9Y6F1 Organism Homo sapiens Gene ADPRT3, ADPRTL3, PARP3 EC 2.4.2.-

Also known as: ADPRT3, ADPRTL3, PARP3

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA. Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ. Suppresses G-quadruplex (G4) structures in response to DNA damage. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks.

Classification

Family (Pfam)
PF00644 PARP, PF02877 PARP_reg, PF05406 WGR
InterPro
ARTD/PARP, Poly(ADP-ribose)pol_cat_dom, Poly(ADP-ribose)pol_reg_dom, Poly(ADP-ribose)pol_reg_dom_sf, WGR_dom_sf, WGR_domain
Functional cluster
Zinc-Finger & Ubiquitination Proteins

Experimental structures · PDB · 16

A predicted model is available from AlphaFold.

Gene Ontology · 24

Drugs targeting this protein · 5

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 19 cited papers

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