lmmol · Proteins

Poly [ADP-ribose] polymerase 2

UniProt Q9UGN5 Organism Homo sapiens Gene ADPRT2, ADPRTL2, PARP2 EC 2.4.2.30, 2.4.2.-

Also known as: ADPRT2, ADPRTL2, PARP2

Function

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site. PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains. Specifically mediates formation of branched poly-ADP-ribosylation. Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF. In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex.

Classification

Family (Pfam)
PF00644 PARP, PF02877 PARP_reg, PF05406 WGR
InterPro
ARTD/PARP, Poly(ADP-ribose)pol_cat_dom, Poly(ADP-ribose)pol_reg_dom, Poly(ADP-ribose)pol_reg_dom_sf, WGR_dom_sf, WGR_domain
Functional cluster
Zinc-Finger & Chromatin Regulatory Proteins

Experimental structures · PDB · 26

A predicted model is available from AlphaFold.

Gene Ontology · 24

Drugs targeting this protein · 12

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 28 cited papers

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