5'-AMP-activated protein kinase subunit beta-1

UniProt Q9Y478 Organism Homo sapiens Gene AMPK, PRKAB1

Also known as: AMPK, PRKAB1

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Classification

Family (Pfam): PF16561 AMPK1_CBM, PF04739 AMPKBI
InterPro: AMPK1_CBM, ASC_dom, ASC_dom_sf, CRP1_MDG1_kinase, Ig-like_fold, Ig_E-set
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 12

4CFE X-ray 3.02A
4CFF X-ray 3.92A
4ZHX X-ray 2.99A
5EZV X-ray 2.99A
5ISO X-ray 2.63A
6B1U X-ray 2.77A
6C9F X-ray 2.92A
6C9G X-ray 2.70A
6C9H X-ray 2.65A
6C9J X-ray 3.05A
7MYJ X-ray 2.95A
8BIK X-ray 2.50A

A predicted model is available from AlphaFold.

Gene Ontology · 11

Drugs targeting this protein · 1

ACADESINE activator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

5'-AMP-activated protein kinase subunit gamma-1 6 shared papers
5'-AMP-activated protein kinase catalytic subunit alpha-1 6 shared papers
5'-AMP-activated protein kinase subunit beta-2 3 shared papers
5'-AMP-activated protein kinase subunit gamma-2 3 shared papers
5'-AMP-activated protein kinase subunit gamma-3 3 shared papers
Folliculin-interacting protein 1 2 shared papers
Folliculin 2 shared papers
5'-AMP-activated protein kinase catalytic subunit alpha-2 3 shared papers
Folliculin-interacting protein 2 1 shared papers
5'-AMP-activated protein kinase subunit beta-2 1 shared papers
5'-AMP-activated protein kinase subunit beta-2 1 shared papers
5'-AMP-activated protein kinase subunit gamma-1 1 shared papers

Literature · 19 cited papers

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
AMPK is a direct adenylate charge-regulated protein kinase. Science · 2011
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy · 2011
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene · 2008
… and 7 more in the literature graph

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