5'-AMP-activated protein kinase subunit gamma-3

UniProt Q9UGI9 Organism Homo sapiens Gene AMPKG3, PRKAG3

Also known as: AMPKG3, PRKAG3

Function

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Classification

Family (Pfam): PF00571 CBS
InterPro: AMPK_gamma/SDS23_families, CBS_dom, CBS_dom_sf
Functional cluster: Eukaryotic Transcription Factors & related

Gene Ontology · 19

Disease associations

obsolete skeletal muscle glycogen content and metabolism quantitative trait locus MONDO:0033571

Drugs targeting this protein · 1

ACADESINE activator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

5'-AMP-activated protein kinase subunit gamma-2 7 shared papers
5'-AMP-activated protein kinase subunit gamma-3 1 shared papers
5'-AMP-activated protein kinase subunit gamma-1 6 shared papers
5'-AMP-activated protein kinase subunit beta-2 3 shared papers
5'-AMP-activated protein kinase subunit beta-1 3 shared papers
5'-AMP-activated protein kinase catalytic subunit alpha-1 4 shared papers
Protein O-GlcNAcase 1 shared papers
5'-AMP-activated protein kinase catalytic subunit alpha-2 3 shared papers
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 shared papers
5'-AMP-activated protein kinase subunit beta-2 1 shared papers
5'-AMP-activated protein kinase subunit beta-2 1 shared papers
5'-AMP-activated protein kinase subunit gamma-1 1 shared papers

Literature · 10 cited papers

Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). J. Biol. Chem. · 2014
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy · 2011
Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle. PLoS ONE · 2007
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. · 2007
AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. · 2007
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. EMBO J. · 2007
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. · 2004
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science · 2000
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem. J. · 2000

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