Ribosomal protein S6 kinase beta-2

Function

Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.

Classification

Family (Pfam)

PF00069 Pkinase, PF00433 Pkinase_C

InterPro

AGC-kinase_C, Kinase-like_dom_sf, Pkinase_C, Prot_kinase_dom, Protein_kinase_ATP_BS, Ribosomal_S6_kinase, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 14

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005524 ATP binding
• GO:0042277 peptide binding
• GO:0004672 protein kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0004711 ribosomal protein S6 kinase activity
• GO:0045948 positive regulation of translational initiation
• GO:0007165 signal transduction
• GO:0031929 TOR signaling
• GO:0038202 TORC1 signaling
• GO:0006412 translation

Drugs targeting this protein · 3

• XL-418 inhibitor
• TAS0612 inhibitor
• RUPITASERTIB inhibitor

Related proteins · sequence + function similarity

• Ribosomal protein S6 kinase beta-2 0.99
• Ribosomal protein S6 kinase beta-1 0.88
• Ribosomal protein S6 kinase beta-1 0.88
• Ribosomal protein S6 kinase beta-1 0.88
• Ribosomal protein S6 kinase beta-1 0.88
• Ribosomal protein S6 kinase beta-1 0.88
• Ribosomal protein S6 kinase alpha-1 0.84
• Ribosomal protein S6 kinase alpha-4 0.84
• Ribosomal protein S6 kinase alpha-1 0.84
• Ribosomal protein S6 kinase alpha-1 0.83
• Ribosomal protein S6 kinase 2 beta 0.83
• Serine/threonine-protein kinase psk1 0.83

Co-cited proteins · studied together in the literature

• Ribosomal protein S6 kinase beta-1 2 shared papers
• Serine/threonine-protein kinase mTOR 2 shared papers
• MTOR-associated protein MEAK7 1 shared papers
• Eukaryotic translation initiation factor 4E-binding protein 1 1 shared papers
• Target of rapamycin complex subunit LST8 1 shared papers

Literature · 14 cited papers

• Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. Sci. Adv. · 2018
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. Mol. Cell. Biol. · 2003
• Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. J. Biol. Chem. · 2002
• Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene · 1999
• … and 2 more in the literature graph