NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

Function

Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.

Classification

Family (Pfam)

PF06784 UPF0240

InterPro

NDUFAF4

Functional cluster

Transcriptional Regulators & Metal Chaperones

Gene Ontology · 6

• GO:0005743 mitochondrial inner membrane
• GO:0031966 mitochondrial membrane
• GO:0005739 mitochondrion
• GO:0005516 calmodulin binding
• GO:0051607 defense response to virus
• GO:0032981 mitochondrial respiratory chain complex I assembly

Disease associations

• mitochondrial complex I deficiency, nuclear type 15 MONDO:0032620

Drugs targeting this protein · 2

• METFORMIN HYDROCHLORIDE inhibitor
• ME-344 inhibitor

Related proteins · sequence + function similarity

• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 0.99
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 0.97
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 0.97
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 0.97
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 0.85
• Small ribosomal subunit protein mS23 0.55
• Large ribosomal subunit protein mL58 0.52
• Small ribosomal subunit protein mS23 0.51
• Small ribosomal subunit protein mS23 0.50
• Small ribosomal subunit protein mS23 0.50
• Small ribosomal subunit protein mS23 0.50
• Small ribosomal subunit protein mS23 0.49

Co-cited proteins · studied together in the literature

• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 1 shared papers
• Matrix protein 1 shared papers
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 1 shared papers
• NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 1 shared papers
• NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 1 shared papers

Literature · 14 cited papers

• The host cellular protein Ndufaf4 interacts with the vesicular stomatitis virus M protein and affects viral propagation. Virus Genes · 2021
• NDUFAF4 variants are associated with Leigh syndrome and cause a specific mitochondrial complex I assembly defect. Eur. J. Hum. Genet. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat. Commun. · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. Am. J. Hum. Genet. · 2009
• C6ORF66 is an assembly factor of mitochondrial complex I. Am. J. Hum. Genet. · 2008
• HRPAP20: a novel calmodulin-binding protein that increases breast cancer cell invasion. Oncogene · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Identification of HRPAP20: a novel phosphoprotein that enhances growth and survival in hormone-responsive tumor cells. Cancer Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 2 more in the literature graph