Solute carrier family 22 member 11

UniProt Q9NSA0 Organism Homo sapiens Gene OAT4, SLC22A11

Also known as: OAT4, SLC22A11

Function

Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds. May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus. Maybe also be involved in placental urate homeostasis. Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates. Organic anion glutarate acts as conteranion for E1S renal uptake. Possible transport mode may also include DHEA-S/E1S exchange. Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-). Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion. Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A. Mediates the unidirectional efflux of glutamate and aspartate. Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S.

Classification

Family (Pfam): PF00083 Sugar_tr
InterPro: MFS_dom, MFS_sugar_transport-like, MFS_trans_sf
Functional cluster: Immunoglobulin & Immune-Response Proteins

Experimental structures · PDB · 3

8WJH EM 3.10A
9M9Y EM 3.04A
9U5A EM 2.98A

A predicted model is available from AlphaFold.

Gene Ontology · 13

Drugs targeting this protein · 1

PROBENECID inhibitor

Related proteins · sequence + function similarity

Solute carrier family 22 member 12 0.97
Solute carrier family 22 member 12 0.97
Solute carrier family 22 member 12 0.95
Solute carrier family 22 member 6 0.94
Solute carrier family 22 member 6 0.94
Solute carrier family 22 member 6 0.94
Organic anion transporter 7 0.93
Solute carrier family 22 member 6 0.93
Steroid transmembrane transporter SLC22A24 0.92
Solute carrier family 22 member 6 0.92
Organic anion transporter 7 0.91
Solute carrier family 22 member 6 0.90

Co-cited proteins · studied together in the literature

Solute carrier organic anion transporter family member 2B1 3 shared papers
Solute carrier family 22 member 7 1 shared papers
Hepatic sodium/bile acid cotransporter 1 shared papers
Solute carrier organic anion transporter family member 4A1 1 shared papers
Solute carrier organic anion transporter family member 3A1 1 shared papers
Organic anion transporter 3 1 shared papers
Solute carrier family 22 member 6 1 shared papers
Solute carrier organic anion transporter family member 1A2 1 shared papers
Solute carrier organic anion transporter family member 1B3 1 shared papers
Solute carrier family 22 member 1 1 shared papers
Solute carrier family 22 member 2 1 shared papers

Literature · 14 cited papers

A novel mode of operation of SLC22A11: Membrane insertion of estrone sulfate versus translocation of uric acid and glutamate. Biochem. Pharmacol. · 2017
Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast. J. Physiol. (Lond.) · 2015
Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. J. Steroid Biochem. Mol. Biol. · 2008
Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J. Am. Soc. Nephrol. · 2007
Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Mol. Pharmacol. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochem. J. · 2004
The role of glycine residues in the function of human organic anion transporter 4. Mol. Pharmacol. · 2004
Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J. Pharmacol. Sci. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Characterization and identification of steroid sulfate transporters of human placenta. Am. J. Physiol. · 2003
… and 2 more in the literature graph

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