Solute carrier family 22 member 12

UniProt Q96S37 Organism Homo sapiens Gene OATL4, SLC22A12, URAT1

Also known as: OATL4, SLC22A12, URAT1

Function

Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent.

Classification

Family (Pfam): PF07690 MFS_1
InterPro: MFS, MFS_dom, MFS_trans_sf
Functional cluster: Secreted Growth Factors & Cytokines

Experimental structures · PDB · 27

8WJG EM 3.00A
8WJQ EM 3.80A
9B1F EM 2.90A
9B1G EM 2.70A
9B1H EM 2.90A
9B1I EM 3.70A
9B1J EM 3.00A
9B1K EM 3.30A
9B1L EM 3.10A
9B1M EM 3.00A
9B1N EM 3.10A
9B1O EM 3.10A
… and 15 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

Disease associations

hypouricemia, renal 1 MONDO:0020728

Drugs targeting this protein · 8

ARHALOFENATE inhibitor
LESINURAD inhibitor
VERINURAD inhibitor
SHR-4640 inhibitor
BENZBROMARONE inhibitor
PRATOSARTAN inhibitor
DOTINURAD inhibitor
SULFINPYRAZONE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Solute carrier family 22 member 13 2 shared papers
Solute carrier family 22 member 13 1 shared papers
Solute carrier family 22 member 13 1 shared papers
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 1 shared papers
Solute carrier family 22 member 4 1 shared papers
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 1 shared papers
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 shared papers

Literature · 18 cited papers

OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Front. Pharmacol. · 2022
Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Drug Metab. Pharmacokinet. · 2022
Hereditary renal hypouricemia type 1 and autosomal dominant polycystic kidney disease. Am. J. Med. Sci. · 2015
Clinical and functional characterization of URAT1 variants. PLoS ONE · 2011
Human urate transporter 1 (hURAT1) mediates the transport of orotate. J. Physiol. Sci. · 2011
Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout. Rheumatology · 2007
Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. Arthritis Rheum. · 2006
Mutational analysis of idiopathic renal hypouricemia in Korea. Pediatr. Nephrol. · 2005
Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. J. Clin. Endocrinol. Metab. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. Kidney Int. · 2004
… and 6 more in the literature graph

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