Gonadotropin-releasing hormone receptor

UniProt Q9MZI6 Organism Canis lupus familiaris Gene GNRHR

Also known as: GNRHR

Function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, GphnRH_fam_rcpt
Functional cluster: Membrane Transporters & GPCRs

Gene Ontology · 4

Drugs targeting this protein · 1

DESLORELIN ACETATE agonist

Related proteins · sequence + function similarity

Literature · 1 cited papers

Identification of Phe313 of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists. Mol. Endocrinol. · 2000

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