Gonadotropin-releasing hormone receptor

UniProt P30968 Organism Homo sapiens Gene GNRHR, GRHR

Also known as: GNRHR, GRHR

Function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, GphnRH_fam_rcpt
Functional cluster: Membrane Transporters & GPCRs

Experimental structures · PDB · 1

7BR3 X-ray 2.79A

A predicted model is available from AlphaFold.

Gene Ontology · 6

Disease associations

hypogonadotropic hypogonadism 7 with or without anosmia MONDO:0007794

Drugs targeting this protein · 23

GOSERELIN ACETATE agonist
HISTRELIN ACETATE agonist
GONADORELIN ACETATE agonist
GONADORELIN HYDROCHLORIDE agonist
TRIPTORELIN PAMOATE agonist
NAFARELIN ACETATE agonist
LEUPROLIDE ACETATE agonist
ELAGOLIX antagonist
GANIRELIX antagonist
ABARELIX antagonist
RELUGOLIX antagonist
DEGARELIX ACETATE antagonist
CETRORELIX ACETATE antagonist
BUSERELIN agonist
SUFUGOLIX antagonist
ACYLINE antagonist
ZOPTARELIN DOXORUBICIN agonist
LINZAGOLIX antagonist
OPIGOLIX antagonist
LINZAGOLIX CHOLINE antagonist
LEUPROLIDE MESYLATE agonist
ELAGOLIX SODIUM antagonist
GANIRELIX ACETATE antagonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Prokineticin-2 2 shared papers
Neuromedin-K receptor 2 shared papers
Prokineticin receptor 2 2 shared papers
Anosmin-1 2 shared papers
Heparan-sulfate 6-O-sulfotransferase 1 1 shared papers
Semaphorin-3A 1 shared papers
Transcription factor SOX-10 1 shared papers
Interleukin-17 receptor D 1 shared papers
KiSS-1 receptor 2 shared papers
ATP-dependent chromatin remodeler CHD7 1 shared papers
NMDA receptor synaptonuclear signaling and neuronal migration factor 1 shared papers
Tachykinin-3 1 shared papers

Literature · 19 cited papers

The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients. J. Clin. Endocrinol. Metab. · 2014
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am. J. Hum. Genet. · 2013
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism. J. Clin. Endocrinol. Metab. · 2003
Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. J. Clin. Endocrinol. Metab. · 2002
Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction. J. Clin. Endocrinol. Metab. · 2001
The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor. J. Clin. Endocrinol. Metab. · 2001
A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene. Clin. Endocrinol. (Oxf.) · 2001
Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor. J. Clin. Endocrinol. Metab. · 1999
Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene. Eur. J. Endocrinol. · 1999
Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration. J. Clin. Endocrinol. Metab. · 1999
The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred. J. Clin. Endocrinol. Metab. · 1999
… and 7 more in the literature graph

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