DNA topoisomerase 4 subunit A
Also known as: PA4964, parC
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Classification
- Family (Pfam)
- PF03989 DNA_gyraseA_C, PF00521 DNA_topoisoIV
- InterPro
- GyrA/parC_rep, Gyrase/topoIV_suA_C, Topo_IIA-like_dom_sf, Topo_IIA_A/C_ab, Topo_IIA_A_a_sf, Topo_IIA_dom_A, TopoIV_A_Gneg, Type_II_DNA_Topoisomerases
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Gene Ontology · 10
- GO:0005694 chromosome
- GO:0005737 cytoplasm
- GO:0009340 DNA topoisomerase IV complex
- GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
- GO:0019897 extrinsic component of plasma membrane
- GO:0005524 ATP binding
- GO:0003677 DNA binding
- GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
- GO:0007059 chromosome segregation
- GO:0006265 DNA topological change
Drugs targeting this protein · 1
- FINAFLOXACIN inhibitor
Related proteins · sequence + function similarity
- DNA topoisomerase 4 subunit A 0.94
- DNA topoisomerase 4 subunit A 0.94
- DNA topoisomerase 4 subunit A 0.94
- DNA topoisomerase 4 subunit A 0.94
- DNA topoisomerase 4 subunit A 0.86
- DNA topoisomerase 4 subunit A 0.82
- DNA topoisomerase 4 subunit A 0.73
- DNA topoisomerase 4 subunit A 0.69
- DNA topoisomerase 4 subunit A 0.69
- DNA topoisomerase 4 subunit A 0.68
- DNA topoisomerase 4 subunit A 0.68
- DNA topoisomerase 4 subunit A 0.65
Literature · 1 cited papers
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