Cytochrome P450 3A43
Also known as: CYP3A43
Function
Exhibits low testosterone 6-beta-hydroxylase activity in vitro. The physiological substrate of this enzyme is unknown.
Classification
- Family (Pfam)
- PF00067 p450
- InterPro
- Cyt_P450, Cyt_P450_CS, Cyt_P450_E_CYP3A, Cyt_P450_E_grp-II, Cyt_P450_sf, Cytochrome_P450_3A
- Functional cluster
- Cytochrome P450 & Heme Enzymes
Gene Ontology · 9
- GO:0005789 endoplasmic reticulum membrane
- GO:0101020 estrogen 16-alpha-hydroxylase activity
- GO:0020037 heme binding
- GO:0005506 iron ion binding
- GO:0004497 monooxygenase activity
- GO:0050649 testosterone 6-beta-hydroxylase activity
- GO:1903604 cytochrome metabolic process
- GO:0070989 oxidative demethylation
- GO:0008202 steroid metabolic process
Drugs targeting this protein · 2
- RITONAVIR inhibitor
- COBICISTAT inhibitor
Related proteins · sequence + function similarity
- Cytochrome P450 3A13 0.97
- Cytochrome P450 3A4 0.97
- Cytochrome P450 3A16 0.97
- Cytochrome P450 3A2 0.97
- Cytochrome P450 3A9 0.96
- Cytochrome P450 3A21 0.96
- Cytochrome P450 3A7 0.96
- Cytochrome P450 3A8 0.96
- Cytochrome P450 3A15 0.96
- Cytochrome P450 3A12 0.96
- Cytochrome P450 3A17 0.96
- Cytochrome P450 3A5 0.96
Co-cited proteins · studied together in the literature
- Cytochrome P450 3A5 2 shared papers
- Cytochrome P450 3A4 2 shared papers
- Cytochrome P450 3A7 1 shared papers
Literature · 8 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- An unappreciated role for RNA surveillance. Genome Biol. · 2004
- First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. Hum. Mutat. · 2004
- The DNA sequence of human chromosome 7. Nature · 2003
- Intergenic mRNA molecules resulting from trans-splicing. J. Biol. Chem. · 2002
- Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics · 2001
- Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43. Biochem. Biophys. Res. Commun. · 2001
- cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol. Pharmacol. · 2001
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