lmmol · Proteins

Cytochrome P450 3A7

UniProt P24462 Organism Homo sapiens Gene CYP3A7 EC 1.14.14.1

Also known as: CYP3A7

Function

A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. Also involved in the oxidative metabolism of xenobiotics including anticonvulsants.

Classification

Family (Pfam)
PF00067 p450
InterPro
Cyt_P450, Cyt_P450_CS, Cyt_P450_E_CYP3A, Cyt_P450_E_grp-II, Cyt_P450_sf, Cytochrome_P450_3A
Functional cluster
Serine/Threonine Protein Kinases

Experimental structures · PDB · 2

A predicted model is available from AlphaFold.

Gene Ontology · 19

Drugs targeting this protein · 2

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 12 cited papers

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