Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

UniProt Q93084 Organism Homo sapiens Gene ATP2A3 EC 7.2.2.10

Also known as: ATP2A3

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Classification

Family (Pfam): PF13246 Cation_ATPase, PF00689 Cation_ATPase_C, PF00690 Cation_ATPase_N, PF00122 E1-E2_ATPase, PF08282 Hydrolase_3
InterPro: ATPase_P-typ_cation-transptr_C, ATPase_P-typ_cation-transptr_N, ATPase_P-typ_cyto_dom_N, ATPase_P-typ_P_site, ATPase_P-typ_TM_dom_sf, ATPase_P-typ_transduc_dom_A_sf, ATPase_P-type_domA, HAD-like_sf, HAD_sf, P-type_ATPase_IIA, P_typ_ATPase, P_typ_ATPase_HD_dom
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 25

Drugs targeting this protein · 1

MIPSAGARGIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Protein TUNAR 1 shared papers
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 1 shared papers
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1 shared papers
Sarcolipin 1 shared papers
Vacuole membrane protein 1 1 shared papers
Phospholamban 1 shared papers
Vacuole membrane protein 1 1 shared papers
WD repeat domain phosphoinositide-interacting protein 2 1 shared papers
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1 shared papers
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1 shared papers
RB1-inducible coiled-coil protein 1 1 shared papers
Serine/threonine-protein kinase ULK1 1 shared papers

Literature · 15 cited papers

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic beta cells. Mol. Ther. Nucleic Acids · 2021
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol. Cell · 2017
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene. J. Biol. Chem. · 2004
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat. Biotechnol. · 2003
Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. J. Biol. Chem. · 2002
Functional characterization of alternatively spliced human SERCA3 transcripts. Am. J. Physiol. · 1998
… and 3 more in the literature graph

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