Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Function

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction.

Classification

Family (Pfam)

PF13246 Cation_ATPase, PF00689 Cation_ATPase_C, PF00690 Cation_ATPase_N, PF00122 E1-E2_ATPase, PF08282 Hydrolase_3

InterPro

ATPase_P-typ_cation-transptr_C, ATPase_P-typ_cation-transptr_N, ATPase_P-typ_cyto_dom_N, ATPase_P-typ_P_site, ATPase_P-typ_TM_dom_sf, ATPase_P-typ_transduc_dom_A_sf, ATPase_P-type_domA, HAD-like_sf, HAD_sf, P-type_ATPase_IIA, P_typ_ATPase, P_typ_ATPase_HD_dom

Functional cluster

GroEL/Cpn60 Chaperonins

Gene Ontology · 38

• GO:0034704 calcium channel complex
• GO:0005789 endoplasmic reticulum membrane
• GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
• GO:0031673 H zone
• GO:0031674 I band
• GO:0016020 membrane
• GO:0005739 mitochondrion
• GO:0048471 perinuclear region of cytoplasm
• GO:0031095 platelet dense tubular network membrane
• GO:0016529 sarcoplasmic reticulum
• GO:0033017 sarcoplasmic reticulum membrane
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0005509 calcium ion binding
• GO:0030899 calcium-dependent ATPase activity
• GO:0005388 P-type calcium transporter activity
• GO:0042803 protein homodimerization activity
• GO:0008637 apoptotic mitochondrial changes
• GO:0070509 calcium ion import
• GO:1990036 calcium ion import into sarcoplasmic reticulum
• GO:0070588 calcium ion transmembrane transport
• GO:0006816 calcium ion transport
• GO:0006874 intracellular calcium ion homeostasis
• GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
• GO:0051659 maintenance of mitochondrion location
• GO:0034220 monoatomic ion transmembrane transport
• GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
• GO:0045988 negative regulation of striated muscle contraction
• GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
• GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
• GO:0106134 positive regulation of cardiac muscle cell contraction
• GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
• GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
• GO:0051561 positive regulation of mitochondrial calcium ion concentration
• GO:1903779 regulation of cardiac conduction
• GO:0006942 regulation of striated muscle contraction
• GO:0090076 relaxation of skeletal muscle
• GO:0034976 response to endoplasmic reticulum stress

Disease associations

• Brody myopathy MONDO:0010977

Drugs targeting this protein · 1

• MIPSAGARGIN inhibitor

Related proteins · sequence + function similarity

• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1.00
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1.00
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 0.99
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 0.99
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 0.99
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 0.99
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.98
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.98
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.98
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.98
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.98
• Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.98

Co-cited proteins · studied together in the literature

• Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1 shared papers
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 1 shared papers
• Sarcolipin 1 shared papers
• Vacuole membrane protein 1 1 shared papers
• Phospholamban 1 shared papers
• Vacuole membrane protein 1 1 shared papers
• WD repeat domain phosphoinositide-interacting protein 2 1 shared papers
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1 shared papers
• Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1 shared papers
• RB1-inducible coiled-coil protein 1 1 shared papers
• Serine/threonine-protein kinase ULK1 1 shared papers
• Calmodulin-1 1 shared papers

Literature · 5 cited papers

• The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol. Cell · 2017
• The sequence and analysis of duplication-rich human chromosome 16. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The mutation of Pro(789) to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1) and is associated with Brody disease. Hum. Genet. · 2000
• Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease. Genomics · 1995