Phosphatidylinositol 3-kinase regulatory subunit gamma
Also known as: PIK3R3
Function
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Classification
- Family (Pfam)
- PF16454 PI3K_P85_iSH2, PF00017 SH2
- InterPro
- PI3K_P85_iSH2, PI3kinase_P85_cSH2, PI3kinase_P85_nSH2, SH2, SH2_dom_sf
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Gene Ontology · 14
- GO:0005829 cytosol
- GO:0005943 phosphatidylinositol 3-kinase complex, class IA
- GO:0016303 1-phosphatidylinositol-3-kinase activity
- GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
- GO:0001784 phosphotyrosine residue binding
- GO:0030183 B cell differentiation
- GO:0002042 cell migration involved in sprouting angiogenesis
- GO:0006955 immune response
- GO:0008286 insulin receptor signaling pathway
- GO:2000811 negative regulation of anoikis
- GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0030335 positive regulation of cell migration
- GO:0010628 positive regulation of gene expression
- GO:0030217 T cell differentiation
Drugs targeting this protein · 23
- PF-04691502 inhibitor
- OMIPALISIB inhibitor
- IZORLISIB inhibitor
- DACTOLISIB inhibitor
- APITOLISIB inhibitor
- BUPARLISIB inhibitor
- AZD-6482 inhibitor
- RECILISIB inhibitor
- SF-1126 inhibitor
- TASELISIB inhibitor
- PILARALISIB inhibitor
- VS-5584 inhibitor
- GSK-1059615 inhibitor
- BGT-226 inhibitor
- VOXTALISIB inhibitor
- PAXALISIB inhibitor
- SONOLISIB inhibitor
- SAMOTOLISIB inhibitor
- PUQUITINIB MESYLATE DIHYDRATE inhibitor
- PANULISIB inhibitor
- PICTILISIB inhibitor
- ZSTK-474 inhibitor
- GEDATOLISIB inhibitor
Related proteins · sequence + function similarity
- Phosphatidylinositol 3-kinase regulatory subunit gamma 0.99
- Phosphatidylinositol 3-kinase regulatory subunit gamma 0.99
- Phosphatidylinositol 3-kinase regulatory subunit gamma 0.98
- Phosphatidylinositol 3-kinase regulatory subunit alpha 0.81
- Phosphatidylinositol 3-kinase regulatory subunit alpha 0.79
- Phosphatidylinositol 3-kinase regulatory subunit alpha 0.79
- Phosphatidylinositol 3-kinase regulatory subunit alpha 0.79
- Phosphatidylinositol 3-kinase regulatory subunit alpha 0.77
- Phosphatidylinositol 3-kinase regulatory subunit alpha 0.73
- Sorting nexin-7 0.66
- Sorting nexin-7 0.66
- Signal transducer and activator of transcription 5A 0.66
Co-cited proteins · studied together in the literature
- Cytoplasmic protein NCK2 1 shared papers
- Tensin-2 1 shared papers
- Suppressor of cytokine signaling 1 1 shared papers
- Tyrosine-protein kinase receptor UFO 1 shared papers
Literature · 4 cited papers
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. Biochem. Biophys. Res. Commun. · 2002
- Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. Gene · 1998
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