Phosphoinositide 3-kinase regulatory subunit 5
Also known as: PIK3R5
Function
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Classification
- Family (Pfam)
- PF10486 PI3K_1B_p101
- InterPro
- PIK3R5/6
- Functional cluster
- Eukaryotic Transcription Factors & related
Gene Ontology · 16
- GO:0034451 centriolar satellite
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0016020 membrane
- GO:0005634 nucleus
- GO:0005942 phosphatidylinositol 3-kinase complex
- GO:0005944 phosphatidylinositol 3-kinase complex, class IB
- GO:0005886 plasma membrane
- GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
- GO:0031683 G-protein beta/gamma-subunit complex binding
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006955 immune response
- GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0046488 phosphatidylinositol metabolic process
- GO:0043406 positive regulation of MAP kinase activity
- GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Disease associations
- ataxia with oculomotor apraxia type 3 MONDO:0014084
Drugs targeting this protein · 23
- PF-04691502 inhibitor
- OMIPALISIB inhibitor
- IZORLISIB inhibitor
- DACTOLISIB inhibitor
- APITOLISIB inhibitor
- BUPARLISIB inhibitor
- AZD-6482 inhibitor
- RECILISIB inhibitor
- SF-1126 inhibitor
- TASELISIB inhibitor
- PILARALISIB inhibitor
- VS-5584 inhibitor
- GSK-1059615 inhibitor
- BGT-226 inhibitor
- VOXTALISIB inhibitor
- PAXALISIB inhibitor
- SONOLISIB inhibitor
- SAMOTOLISIB inhibitor
- PUQUITINIB MESYLATE DIHYDRATE inhibitor
- PANULISIB inhibitor
- PICTILISIB inhibitor
- ZSTK-474 inhibitor
- GEDATOLISIB inhibitor
Related proteins · sequence + function similarity
- Phosphoinositide 3-kinase regulatory subunit 5 0.99
- Phosphoinositide 3-kinase regulatory subunit 5 0.99
- Phosphoinositide 3-kinase regulatory subunit 5 0.93
- Phosphoinositide 3-kinase regulatory subunit 6 0.92
- Phosphoinositide 3-kinase regulatory subunit 6 0.91
- Phosphoinositide 3-kinase regulatory subunit 5 0.85
- Sphingosine kinase 2 0.73
- Sphingosine kinase 2 0.71
- Serine/threonine-protein kinase 11-interacting protein 0.69
- Serine/threonine-protein kinase 11-interacting protein 0.67
- Fanconi anemia core complex-associated protein 100 0.67
- Protein FAM178B 0.66
Co-cited proteins · studied together in the literature
- Phosphoinositide 3-kinase regulatory subunit 6 1 shared papers
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1 shared papers
Literature · 5 cited papers
- A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia. Hum. Mutat. · 2012
- Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr. Biol. · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.