Probable aminopeptidase NPEPL1

Function

Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Classification

Family (Pfam)

PF18295 Pdase_M17_N2, PF00883 Peptidase_M17

InterPro

Leucine_aapep/pepB, NPEPL1_N, Peptidase_M17_C

Functional cluster

Oxidoreductases & Polyketide Synthases

Gene Ontology · 6

• GO:0005737 cytoplasm
• GO:0005634 nucleus
• GO:0030145 manganese ion binding
• GO:0070006 metalloaminopeptidase activity
• GO:0008233 peptidase activity
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Probable aminopeptidase NPEPL1 1.00
• Probable aminopeptidase NPEPL1 0.99
• Aminopeptidase grsm 0.87
• Leucine aminopeptidase 1 0.85
• Putative aminopeptidase W07G4.4 0.75
• Putative leucine aminopeptidase 1 0.71
• Leucine aminopeptidase 1 0.71
• Cytosol aminopeptidase 0.70
• Putative aminopeptidase C13A11.05 0.70
• Cytosol aminopeptidase 0.70
• Cytosol aminopeptidase 0.69
• Cytosol aminopeptidase 0.69

Literature · 5 cited papers

• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res. · 2001
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001