Protein TOPAZ1

UniProt Q8N9V7 Organism Homo sapiens Gene C3orf77, TOPAZ1

Also known as: C3orf77, TOPAZ1

Function

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.

Classification

Family (Pfam): PF14669 Asp_Glu_race_2
InterPro: TOPAZ1, TOPAZ1_dom
Functional cluster: Zinc-Finger & Chromatin Regulatory Proteins

Gene Ontology · 3

Neighborhood · nearest proteins

Nearest neighbours of Protein TOPAZ1: 3 by sequence/function similarity (left).

Related proteins · sequence + function similarity

Protein TOPAZ1 1.00
Protein TOPAZ1 0.99
Protein TOPAZ1 0.99
Protein TOPAZ1 0.99
Protein TOPAZ1 0.98
Protein TOPAZ1 0.97
Protein TOPAZ1 0.97
Protein TOPAZ1 0.96
Breast cancer type 1 susceptibility protein homolog 0.94
Breast cancer type 1 susceptibility protein homolog 0.94
Breast cancer type 1 susceptibility protein 0.94
Breast cancer type 1 susceptibility protein homolog 0.93

Literature · 4 cited papers

The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004

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