Tryptophan 5-hydroxylase 2

Classification

Family (Pfam)

PF00351 Biopterin_H

InterPro

ACT-like_dom_sf, ACT_dom, ArAA_hydroxylase, ArAA_hydroxylase_Fe/CU_BS, ArAA_hydroxylase_sf, Aro-AA_hydroxylase_C_sf, Aromatic-AA_hydroxylase_C, Trp_5_mOase, TrpOH_cat, Tyrosine_3-monooxygenase-like

Functional cluster

Oxidoreductases, Catalases & Peroxidases

Experimental structures · PDB · 5

• 4V06 X-ray 2.63A
• 7QRI NMR
• 7WIY EM 3.09A
• 9HB7 X-ray 2.96A
• 9HB8 X-ray 2.90A

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0005829 cytosol
• GO:0043005 neuron projection
• GO:0005506 iron ion binding
• GO:0004510 tryptophan 5-monooxygenase activity
• GO:0009072 aromatic amino acid metabolic process
• GO:0042427 serotonin biosynthetic process

Disease associations

• major depressive disorder MONDO:0002009
• attention deficit-hyperactivity disorder, susceptibility to, 7 MONDO:0013076

Drugs targeting this protein · 3

• TELOTRISTAT inhibitor
• TELOTRISTAT ETHYL inhibitor
• TELOTRISTAT ETIPRATE inhibitor

Related proteins · sequence + function similarity

• Tryptophan 5-hydroxylase 2 0.99
• Tryptophan 5-hydroxylase 2 0.99
• Tryptophan 5-hydroxylase 2 0.99
• Tryptophan 5-hydroxylase 2 0.99
• Tryptophan 5-hydroxylase 0.94
• Tryptophan 5-hydroxylase 1 0.93
• Tryptophan 5-hydroxylase 1 0.93
• Tryptophan 5-hydroxylase 1 0.91
• Tryptophan 5-hydroxylase 1 0.90
• Tryptophan 5-hydroxylase 1 0.90
• Protein henna 0.89
• Phenylalanine-4-hydroxylase 0.88

Co-cited proteins · studied together in the literature

• Tryptophan 5-hydroxylase 2 1 shared papers
• Tryptophan 5-hydroxylase 2 1 shared papers

Literature · 9 cited papers

• The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity. Biochem. Biophys. Rep. · 2023
• Alternative splicing and extensive RNA editing of human TPH2 transcripts. PLoS ONE · 2010
• Functional properties of missense variants of human tryptophan hydroxylase 2. Hum. Mutat. · 2009
• A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder. Mol. Psychiatry · 2008
• Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. Hum. Mol. Genet. · 2008
• The finished DNA sequence of human chromosome 12. Nature · 2006
• Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science · 2003