Tryptophan 5-hydroxylase 1

Function

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.

Classification

Family (Pfam)

PF00351 Biopterin_H

InterPro

ACT-like_dom_sf, ACT_dom, ArAA_hydroxylase, ArAA_hydroxylase_Fe/CU_BS, ArAA_hydroxylase_sf, Aro-AA_hydroxylase_C_sf, Aromatic-AA_hydroxylase_C, Trp_5_mOase, TrpOH_cat, Tyrosine_3-monooxygenase-like

Functional cluster

M20 Family Metallopeptidases

Experimental structures · PDB · 20

• 1MLW X-ray 1.71A
• 3HF6 X-ray 1.80A
• 3HF8 X-ray 1.85A
• 3HFB X-ray 1.92A
• 5J6D X-ray 1.90A
• 5L01 X-ray 1.90A
• 5TPG X-ray 1.50A
• 7ZIF X-ray 1.87A
• 7ZIG X-ray 1.81A
• 7ZIH X-ray 1.47A
• 7ZII X-ray 1.63A
• 7ZIJ X-ray 1.95A
• … and 8 more

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0005829 cytosol
• GO:0043005 neuron projection
• GO:0005506 iron ion binding
• GO:0004510 tryptophan 5-monooxygenase activity
• GO:0002576 platelet degranulation
• GO:1900046 regulation of hemostasis
• GO:0042427 serotonin biosynthetic process
• GO:0006587 serotonin biosynthetic process from L-tryptophan

Drugs targeting this protein · 4

• TELOTRISTAT inhibitor
• TELOTRISTAT ETHYL inhibitor
• TELOTRISTAT ETIPRATE inhibitor
• RODATRISTAT ETHYL inhibitor

Related proteins · sequence + function similarity

• Tryptophan 5-hydroxylase 1 0.99
• Tryptophan 5-hydroxylase 1 0.98
• Tryptophan 5-hydroxylase 1 0.97
• Tryptophan 5-hydroxylase 1 0.96
• Tryptophan 5-hydroxylase 0.95
• Phenylalanine-4-hydroxylase 0.94
• Phenylalanine-4-hydroxylase 0.94
• Phenylalanine-4-hydroxylase 0.94
• Phenylalanine-4-hydroxylase 0.93
• Tryptophan 5-hydroxylase 2 0.91
• Tryptophan 5-hydroxylase 2 0.91
• Protein henna 0.90

Co-cited proteins · studied together in the literature

• Tryptophan 5-hydroxylase 1 1 shared papers

Literature · 5 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry · 2002
• Alternative splicing at the 3'-cDNA of human tryptophan hydroxylase. J. Neurochem. · 1998
• Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli. Arch. Biochem. Biophys. · 1994
• Complete coding sequence of human tryptophan hydroxylase. Nucleic Acids Res. · 1990