Serine/threonine-protein kinase pim-3

Function

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

Kinase-like_dom_sf, PIM1/2/3, PIM_Ser/Thr_kinase, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 10

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005524 ATP binding
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0006915 apoptotic process
• GO:1904322 cellular response to forskolin
• GO:0043066 negative regulation of apoptotic process
• GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
• GO:0007346 regulation of mitotic cell cycle

Drugs targeting this protein · 3

• SGI-1776 inhibitor
• AZD-1208 inhibitor
• LGH-447 inhibitor

Related proteins · sequence + function similarity

• Serine/threonine-protein kinase pim-3 0.99
• Serine/threonine-protein kinase pim-3 0.99
• Serine/threonine-protein kinase pim-3 0.84
• Serine/threonine-protein kinase pim-2 0.82
• Serine/threonine-protein kinase pim-1 0.81
• Serine/threonine-protein kinase pim-3 0.81
• Serine/threonine-protein kinase pim-1 0.80
• Serine/threonine-protein kinase pim-1 0.80
• Serine/threonine-protein kinase pim-1 0.78
• Serine/threonine-protein kinase pim-1 0.78
• Serine/threonine-protein kinase pim-2 0.74
• Testis-specific serine/threonine-protein kinase 6 0.74

Co-cited proteins · studied together in the literature

• Bcl2-associated agonist of cell death 2 shared papers
• Serine/threonine-protein kinase pim-1 2 shared papers
• Serine/threonine-protein kinase pim-2 1 shared papers
• Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 shared papers
• Forkhead box protein O3 1 shared papers
• Cyclin-dependent kinase inhibitor 1B 1 shared papers

Literature · 10 cited papers

• Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. · 2008
• Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression. J. Cancer Res. Clin. Oncol. · 2008
• Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci. · 2007
• Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res. · 2006
• The transcriptional landscape of the mammalian genome. Science · 2005
• Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int. J. Cancer · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Consistency checks for characterizing protein forms. Comput. Biol. Chem. · 2003
• Protein phosphatase 2A regulates the stability of Pim protein kinases. J. Biol. Chem. · 2003
• The DNA sequence of human chromosome 22. Nature · 1999