Methionine aminopeptidase 1D, mitochondrial
Also known as: MAP1D, METAP1D
Function
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.
Classification
- Family (Pfam)
- PF00557 Peptidase_M24
- InterPro
- Creatinase/aminopeptidase-like, Pept_M24, Pept_M24_MAP, Pept_M24A_MAP1
- Functional cluster
- Chloroplast & RuBisCO Photosynthetic Proteins
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 8
Drugs targeting this protein · 1
- TOSEDOSTAT inhibitor
Related proteins · sequence + function similarity
- Methionine aminopeptidase 1D, mitochondrial 0.97
- Methionine aminopeptidase 1D, mitochondrial 0.91
- Methionine aminopeptidase 1D, chloroplastic/mitochondrial 0.91
- Methionine aminopeptidase 1C, chloroplastic/mitochondrial 0.88
- Methionine aminopeptidase 1B, chloroplastic 0.84
- Methionine aminopeptidase 1 0.77
- Methionine aminopeptidase 1 0.76
- Methionine aminopeptidase 1 0.76
- Methionine aminopeptidase 1 0.76
- Methionine aminopeptidase 1 0.75
- Methionine aminopeptidase 1 0.75
- Methionine aminopeptidase 1A 0.75
Co-cited proteins · studied together in the literature
- Peptide deformylase, mitochondrial 1 shared papers
Literature · 5 cited papers
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases. Biochemistry · 2007
- MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. Oncogene · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. J. Biol. Chem. · 2003
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