Methionine aminopeptidase 1

Function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.

Classification

Family (Pfam)

PF00557 Peptidase_M24, PF15801 zf-C6H2

InterPro

Creatinase/aminopeptidase-like, Pept_M24, Pept_M24_MAP, Pept_M24A_MAP1, Zfn-C6H2

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 41

• 2B3H X-ray 1.10A
• 2B3K X-ray 1.55A
• 2B3L X-ray 1.50A
• 2G6P X-ray 1.90A
• 2GZ5 X-ray 1.10A
• 2NQ6 X-ray 1.50A
• 2NQ7 X-ray 1.60A
• 4FLI X-ray 1.55A
• 4FLJ X-ray 1.74A
• 4FLK X-ray 1.47A
• 4FLL X-ray 1.50A
• 4HXX X-ray 2.09A
• … and 29 more

A predicted model is available from AlphaFold.

Gene Ontology · 11

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0004177 aminopeptidase activity
• GO:0004239 initiator methionyl aminopeptidase activity
• GO:0070006 metalloaminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0008270 zinc ion binding
• GO:0070527 platelet aggregation
• GO:0051604 protein maturation
• GO:0006508 proteolysis
• GO:0006417 regulation of translation

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Methionine aminopeptidase 1 1.00
• Methionine aminopeptidase 1 1.00
• Methionine aminopeptidase 1 1.00
• Methionine aminopeptidase 1 0.99
• Methionine aminopeptidase 1 0.98
• Methionine aminopeptidase 1 0.98
• Methionine aminopeptidase 1 0.97
• Methionine aminopeptidase 1A 0.95
• Methionine aminopeptidase 1 0.93
• Methionine aminopeptidase 1 0.91
• Methionine aminopeptidase 1 0.88
• Methionine aminopeptidase 1D, chloroplastic/mitochondrial 0.81

Literature · 11 cited papers

• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc. Natl. Acad. Sci. U.S.A. · 2006
• Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase. Protein Sci. · 2006
• Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. Angew. Chem. Int. Ed. · 2006
• Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. · 1995