Mitogen-activated protein kinase kinase kinase 11
Also known as: MAP3K11, MLK3, PTK1, SPRK
Function
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Classification
- Family (Pfam)
- PF07714 PK_Tyr_Ser-Thr, PF14604 SH3_9
- InterPro
- Kinase-like_dom_sf, MLK1-3_SH3, MLK1-4, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser-Thr/Tyr_kinase_cat_dom, Ser/Thr_kinase_AS, Ser/Thr_Kinases-Pseudokinases, SH3-like_dom_sf, SH3_domain
- Functional cluster
- Eukaryotic Transcription Factors & related
Experimental structures · PDB · 4
A predicted model is available from AlphaFold.
Gene Ontology · 24
- GO:0034451 centriolar satellite
- GO:0005813 centrosome
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0016020 membrane
- GO:0005874 microtubule
- GO:0005524 ATP binding
- GO:0042802 identical protein binding
- GO:0004706 JUN kinase kinase kinase activity
- GO:0004709 MAP kinase kinase kinase activity
- GO:0031434 mitogen-activated protein kinase kinase binding
- GO:0031435 mitogen-activated protein kinase kinase kinase binding
- GO:0042803 protein homodimerization activity
- GO:0004672 protein kinase activity
- GO:0106310 protein serine kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0031267 small GTPase binding
- GO:0044843 cell cycle G1/S phase transition
- GO:0007254 JNK cascade
- GO:0000165 MAPK cascade
- GO:0007017 microtubule-based process
- GO:0046330 positive regulation of JNK cascade
- GO:0043525 positive regulation of neuron apoptotic process
- GO:0006468 protein phosphorylation
Drugs targeting this protein · 1
- CEP-1347 inhibitor
Related proteins · sequence + function similarity
- Mitogen-activated protein kinase kinase kinase 11 0.99
- Mitogen-activated protein kinase kinase kinase 11 0.99
- Mitogen-activated protein kinase kinase kinase 10 0.92
- Mitogen-activated protein kinase kinase kinase 10 0.91
- Mitogen-activated protein kinase kinase kinase 10 0.91
- Dual specificity testis-specific protein kinase 1 0.89
- Dual specificity testis-specific protein kinase 1 0.88
- Dual specificity testis-specific protein kinase 1 0.88
- Non-receptor tyrosine-protein kinase TNK1 0.87
- Non-receptor tyrosine-protein kinase TNK1 0.86
- Mitogen-activated protein kinase kinase kinase 21 0.85
- Mitogen-activated protein kinase kinase kinase 12 0.85
Co-cited proteins · studied together in the literature
- Dual specificity mitogen-activated protein kinase kinase 4 1 shared papers
Literature · 19 cited papers
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
- Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
- A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
- Patterns of somatic mutation in human cancer genomes. Nature · 2007
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. · 2006
- Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nat. Cell Biol. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- … and 7 more in the literature graph
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