Mitogen-activated protein kinase kinase kinase 10
Also known as: MAP3K10, MLK2, MST
Function
Activates the JUN N-terminal pathway.
Classification
- Family (Pfam)
- PF07714 PK_Tyr_Ser-Thr, PF14604 SH3_9
- InterPro
- Kinase-like_dom_sf, MLK1-3_SH3, MLK1-4, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser-Thr/Tyr_kinase_cat_dom, Ser/Thr_kinase_AS, Ser/Thr_Kinases-Pseudokinases, SH3-like_dom_sf, SH3_domain
- Functional cluster
- Eukaryotic Transcription Factors & related
Experimental structures · PDB · 1
- 2RF0 X-ray 2.00A
A predicted model is available from AlphaFold.
Gene Ontology · 16
- GO:0005737 cytoplasm
- GO:0005524 ATP binding
- GO:0043425 bHLH transcription factor binding
- GO:0004706 JUN kinase kinase kinase activity
- GO:0004672 protein kinase activity
- GO:0106310 protein serine kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0003714 transcription corepressor activity
- GO:0006915 apoptotic process
- GO:0007254 JNK cascade
- GO:0045892 negative regulation of DNA-templated transcription
- GO:0000122 negative regulation of transcription by RNA polymerase II
- GO:0043065 positive regulation of apoptotic process
- GO:0046330 positive regulation of JNK cascade
- GO:0007165 signal transduction
- GO:0007224 smoothened signaling pathway
Drugs targeting this protein · 1
- CEP-1347 inhibitor
Related proteins · sequence + function similarity
- Mitogen-activated protein kinase kinase kinase 10 0.99
- Mitogen-activated protein kinase kinase kinase 10 0.99
- Mitogen-activated protein kinase kinase kinase 11 0.91
- Mitogen-activated protein kinase kinase kinase 11 0.91
- Mitogen-activated protein kinase kinase kinase 11 0.90
- Mitogen-activated protein kinase kinase kinase 9 0.88
- Mitogen-activated protein kinase kinase kinase 21 0.87
- Mitogen-activated protein kinase kinase kinase 9 0.86
- Mitogen-activated protein kinase kinase kinase 12 0.86
- Mitogen-activated protein kinase kinase kinase 12 0.84
- Mitogen-activated protein kinase kinase kinase 12 0.83
- PH and SEC7 domain-containing protein 1 0.83
Co-cited proteins · studied together in the literature
- Mitogen-activated protein kinase kinase kinase 9 1 shared papers
Literature · 6 cited papers
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
- Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
- Patterns of somatic mutation in human cancer genomes. Nature · 2007
- Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. Eur. J. Biochem. · 1995
- Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. Eur. J. Biochem. · 1993
- Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. Oncogene · 1995
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