Histone-binding protein RBBP7

Function

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Classification

Family (Pfam)

PF12265 CAF1C_H4-bd, PF00400 WD40

InterPro

Histone-bd_RBBP4-like_N, WD40/YVTN_repeat-like_dom_sf, WD40_PAC1, WD40_repeat_CS, WD40_repeat_dom_sf, WD40_rpt, WD_repeat_RBAP46/RBAP48/MSI1

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 3

• 3CFS X-ray 2.40A
• 3CFV X-ray 2.60A
• 7M3X X-ray 1.46A

A predicted model is available from AlphaFold.

Gene Ontology · 28

• GO:0000781 chromosome, telomeric region
• GO:0005737 cytoplasm
• GO:0035098 ESC/E(Z) complex
• GO:0000118 histone deacetylase complex
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0016581 NuRD complex
• GO:0016589 NURF complex
• GO:0042393 histone binding
• GO:0003723 RNA binding
• GO:0007420 brain development
• GO:0070370 cellular heat acclimation
• GO:0006338 chromatin remodeling
• GO:0006260 DNA replication
• GO:0006351 DNA-templated transcription
• GO:0031507 heterochromatin formation
• GO:0030308 negative regulation of cell growth
• GO:0030336 negative regulation of cell migration
• GO:0045892 negative regulation of DNA-templated transcription
• GO:1902455 negative regulation of stem cell population maintenance
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
• GO:0045893 positive regulation of DNA-templated transcription
• GO:1902459 positive regulation of stem cell population maintenance
• GO:0042659 regulation of cell fate specification
• GO:0006355 regulation of DNA-templated transcription
• GO:2000736 regulation of stem cell differentiation
• GO:0048545 response to steroid hormone

Disease associations

• spermatogenic failure, X-linked, 9 MONDO:0976123

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Histone-binding protein RBBP7 1.00
• Histone-binding protein RBBP7 1.00
• Histone-binding protein RBBP7 1.00
• Histone-binding protein RBBP7 0.99
• Histone-binding protein RBBP7 0.99
• Histone-binding protein RBBP7 0.98
• Histone-binding protein RBBP7 0.98
• Chromatin assembly factor 1 p55 subunit 0.98
• Histone-binding protein RBBP7 0.95
• Histone-binding protein RBBP4-A 0.93
• Histone-binding protein RBBP4-B 0.92
• Histone-binding protein RBBP4 0.91

Co-cited proteins · studied together in the literature

• Histone-binding protein RBBP4 21 shared papers
• Histone-binding protein RBBP4 2 shared papers
• Histone acetyltransferase type B catalytic subunit 1 shared papers
• Metastasis-associated protein MTA2 1 shared papers
• Histone deacetylase complex subunit SAP18 1 shared papers
• Inhibitor of growth protein 2 1 shared papers
• Nucleosome-remodeling factor subunit BPTF 2 shared papers
• SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 2 shared papers
• Methyl-CpG-binding domain protein 3 6 shared papers
• Cyclin-dependent kinase 2-associated protein 1 4 shared papers
• Methyl-CpG-binding domain protein 2 6 shared papers
• Histone deacetylase complex subunit SAP30 1 shared papers

Literature · 39 cited papers

• X-linked RBBP7 mutation causes maturation arrest and testicular tumors. J. Clin. Invest. · 2023
• Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure. Am. J. Hum. Genet. · 2022
• Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. FEBS J. · 2021
• CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. Nucleic Acids Res. · 2017
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• SUMO-2 orchestrates chromatin modifiers in response to DNA damage. Cell Rep. · 2015
• Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. Dev. Cell · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• … and 27 more in the literature graph