Histone-binding protein RBBP4

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair. Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression. Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling. Component of the PRC2 complex, which promotes repression of homeotic genes during development. Component of the NURF (nucleosome remodeling factor) complex.

Classification

Family (Pfam)

PF12265 CAF1C_H4-bd, PF00400 WD40

InterPro

Histone-bd_RBBP4-like_N, WD40/YVTN_repeat-like_dom_sf, WD40_PAC1, WD40_repeat_CS, WD40_repeat_dom_sf, WD40_rpt, WD_repeat_RBAP46/RBAP48/MSI1

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 48

• 2XU7 X-ray 1.90A
• 3GFC X-ray 2.30A
• 4PBY X-ray 2.50A
• 4PBZ X-ray 2.15A
• 4PC0 X-ray 2.50A
• 4R7A X-ray 1.85A
• 5FXY X-ray 3.20A
• 5VTB X-ray 2.40A
• 5WAI X-ray 2.90A
• 5WAK X-ray 3.20A
• 5XWR X-ray 2.69A
• 5XXQ X-ray 1.90A
• … and 36 more

A predicted model is available from AlphaFold.

Gene Ontology · 34

• GO:0033186 CAF-1 complex
• GO:0000785 chromatin
• GO:0000781 chromosome, telomeric region
• GO:0035098 ESC/E(Z) complex
• GO:0000118 histone deacetylase complex
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0016581 NuRD complex
• GO:0016589 NURF complex
• GO:0032991 protein-containing complex
• GO:0070822 Sin3-type complex
• GO:0042393 histone binding
• GO:0042826 histone deacetylase binding
• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0007420 brain development
• GO:0006338 chromatin remodeling
• GO:0006281 DNA repair
• GO:0006260 DNA replication
• GO:0006335 DNA replication-dependent chromatin assembly
• GO:0006351 DNA-templated transcription
• GO:0031507 heterochromatin formation
• GO:0030336 negative regulation of cell migration
• GO:0008285 negative regulation of cell population proliferation
• GO:0045892 negative regulation of DNA-templated transcription
• GO:1902455 negative regulation of stem cell population maintenance
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
• GO:0006334 nucleosome assembly
• GO:0045893 positive regulation of DNA-templated transcription
• GO:1902459 positive regulation of stem cell population maintenance
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0042659 regulation of cell fate specification
• GO:0006355 regulation of DNA-templated transcription
• GO:2000736 regulation of stem cell differentiation

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Histone-binding protein RBBP4 1.00
• Histone-binding protein RBBP4 1.00
• Histone-binding protein RBBP4 1.00
• Histone-binding protein RBBP4 1.00
• Histone-binding protein RBBP4-B 1.00
• Histone-binding protein RBBP4 0.99
• Histone-binding protein RBBP4-A 0.99
• Histone-binding protein RBBP7 0.97
• Histone-binding protein RBBP7 0.96
• Histone-binding protein RBBP7 0.95
• Chromatin assembly factor 1 p55 subunit 0.92
• Histone-binding protein RBBP7 0.91

Co-cited proteins · studied together in the literature

• Histone-binding protein RBBP7 21 shared papers
• Zinc finger protein 512B 1 shared papers
• Zinc finger protein 827 1 shared papers
• Histone-binding protein RBBP4 1 shared papers
• PHD finger protein 6 1 shared papers
• Zinc finger protein AEBP2 3 shared papers
• Metastasis-associated protein MTA1 5 shared papers
• Histone-binding protein RBBP4 2 shared papers
• Histone acetyltransferase type B catalytic subunit 1 shared papers
• Polycomb protein SUZ12 5 shared papers
• Protein Jumonji 2 shared papers
• Metastasis-associated protein MTA2 1 shared papers

Literature · 55 cited papers

• ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner. Nucleic Acids Res. · 2024
• Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. FEBS J. · 2021
• A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin. Mol. Cell · 2020
• Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Res. · 2019
• Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres. Biochem. J. · 2018
• Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4. Nat. Commun. · 2018
• Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell · 2018
• CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. Nucleic Acids Res. · 2017
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PLoS ONE · 2015
• System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. Mol. Cell. Proteomics · 2015
• Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex. J. Biol. Chem. · 2014
• … and 43 more in the literature graph