lmmol · Proteins

Sodium channel protein type 9 subunit alpha

UniProt Q15858 Organism Homo sapiens Gene NENA, SCN9A

Also known as: NENA, SCN9A

Function

Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain.

Classification

Family (Pfam)
PF00520 Ion_trans, PF24609 IQ_SCN5A_C, PF06512 Na_trans_assoc, PF11933 Na_trans_cytopl
InterPro
Ion_trans_dom, IQ_motif_EF-hand-BS, IQ_SCN5A_C, Na_channel_asu, Na_chnl_inactivation_gate, Na_trans_assoc_dom, Na_trans_cytopl, VGCC_Ca_Na, Volt_channel_dom_sf
Functional cluster
DEAD-Box RNA Helicases & Biogenesis Factors

Experimental structures · PDB · 41

A predicted model is available from AlphaFold.

Gene Ontology · 15

Disease associations

Drugs targeting this protein · 58

Neighborhood · nearest proteins

NENAScn9aSCN9AKiaa4197Alpha-toxin C…SCN11AHuwentoxin-IV
Nearest neighbours of Sodium channel protein type 9 subunit alpha: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 38 cited papers

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