PCNA-associated factor
Also known as: KIAA0101, NS5ATP9, PAF, PCLAF
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Classification
- Family (Pfam)
- PF15715 PAF
- InterPro
- PCNA-AF, PCNA-AF_dom
- Functional cluster
- Zinc-Finger & Chromatin Regulatory Proteins
Experimental structures · PDB · 4
A predicted model is available from AlphaFold.
Gene Ontology · 13
- GO:0005813 centrosome
- GO:0005654 nucleoplasm
- GO:0005634 nucleus
- GO:0048471 perinuclear region of cytoplasm
- GO:0003682 chromatin binding
- GO:0060090 molecular adaptor activity
- GO:0007098 centrosome cycle
- GO:0006974 DNA damage response
- GO:0006281 DNA repair
- GO:0006260 DNA replication
- GO:0051726 regulation of cell cycle
- GO:0009411 response to UV
- GO:0019985 translesion synthesis
Neighborhood · nearest proteins
Related proteins · sequence + function similarity
- PCNA-associated factor 0.99
- PCNA-associated factor 0.98
- PCNA-associated factor 0.98
- PCNA-associated factor 0.88
- PCNA-associated factor 0.87
- Securin 0.51
- Securin-2 0.51
- Securin 0.50
- Putative pituitary tumor-transforming gene 3 protein 0.50
- Securin 0.50
- Securin 0.49
- Securin 0.49
Co-cited proteins · studied together in the literature
- DNA sliding clamp PCNA 2 shared papers
- Breast cancer type 1 susceptibility protein 1 shared papers
- Myb/SANT-like DNA-binding domain-containing protein 3 1 shared papers
- SIN3-HDAC complex-associated factor 1 shared papers
- Protein TMED8 1 shared papers
- PDZ and LIM domain protein 5 1 shared papers
- Coiled-coil domain-containing protein 34 1 shared papers
- NBPF family member NBPF3 1 shared papers
- Nucleolar protein 11 1 shared papers
- Tubulin polyglutamylase complex subunit 2 1 shared papers
- Protein HEXIM2 1 shared papers
- Jupiter microtubule associated homolog 2 1 shared papers
Literature · 18 cited papers
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat. Cell Biol. · 2012
- KIAA0101 is overexpressed, and promotes growth and invasion in adrenal cancer. PLoS ONE · 2011
- Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol. Cell · 2011
- KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol. Cancer Res. · 2011
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc. Natl. Acad. Sci. U.S.A. · 2011
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
- ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. Cell Death Differ. · 2009
- A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
- Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
- The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Exp. Cell Res. · 2006
- … and 6 more in the literature graph
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