Sodium/potassium-transporting ATPase subunit alpha-4

UniProt Q13733 Organism Homo sapiens Gene ATP1A4, ATP1AL2 EC 7.2.2.13

Also known as: ATP1A4, ATP1AL2

Function

Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze. Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity).

Classification

Family (Pfam): PF13246 Cation_ATPase, PF00689 Cation_ATPase_C, PF00690 Cation_ATPase_N, PF00122 E1-E2_ATPase
InterPro: ATPase_P-typ_cation-transptr_C, ATPase_P-typ_cation-transptr_N, ATPase_P-typ_cyto_dom_N, ATPase_P-typ_P_site, ATPase_P-typ_TM_dom_sf, ATPase_P-typ_transduc_dom_A_sf, ATPase_P-type_domA, Cation_transp_ATPase_P-type, HAD-like_sf, HAD_sf, P-type_ATPase_IIC, P_typ_ATPase, P_typ_ATPase_HD_dom
Functional cluster: Oxidoreductases, Catalases & Peroxidases

Experimental structures · PDB · 1

8ZYJ EM 2.37A

A predicted model is available from AlphaFold.

Gene Ontology · 27

Drugs targeting this protein · 6

DESLANOSIDE inhibitor
DIGOXIN inhibitor
ISTAROXIME inhibitor
DIGITOXIN inhibitor
ACETYLDIGITOXIN inhibitor
LANATOSIDE C inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Sodium/potassium-transporting ATPase subunit alpha-4 1 shared papers

Literature · 8 cited papers

Molecular Structure of the Na+,K+-ATPase alpha4beta1 Isoform in Its Ouabain-Bound Conformation. Int. J. Mol. Sci. · 2024
The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility. Mol. Hum. Reprod. · 2006
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. Mol. Reprod. Dev. · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4. Gene · 2002
A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. Proc. Natl. Acad. Sci. U.S.A. · 1994

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