lmmol · Proteins

Activin receptor type-1

UniProt Q04771 Organism Homo sapiens Gene ACVR1, ACVRLK2 EC 2.7.11.30

Also known as: ACVR1, ACVRLK2

Function

Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity).

Classification

Family (Pfam)
PF01064 Activin_recp, PF07714 PK_Tyr_Ser-Thr, PF08515 TGF_beta_GS
InterPro
Activin_recp, GS_dom, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser-Thr/Tyr_kinase_cat_dom, Ser/Thr_kinase_AS, Snake_toxin-like_sf, TGFB_receptor
Functional cluster
Zinc-Finger Nucleic-Acid-Binding & Methyltransferases

Experimental structures · PDB · 85

A predicted model is available from AlphaFold.

Gene Ontology · 52

Disease associations

Drugs targeting this protein · 2

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 18 cited papers

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