Sodium channel protein type 7 subunit alpha
Also known as: SCN6A, SCN7A
Function
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis.
Classification
- Family (Pfam)
- PF00520 Ion_trans, PF24609 IQ_SCN5A_C, PF06512 Na_trans_assoc
- InterPro
- Ion_trans_dom, IQ_SCN5A_C, Na_channel_asu, Na_chnl_inactivation_gate, Na_trans_assoc_dom, VGCC_Ca_Na, Volt_channel_dom_sf
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 12
- GO:0097386 glial cell projection
- GO:0005886 plasma membrane
- GO:0001518 voltage-gated sodium channel complex
- GO:1990760 osmolarity-sensing monoatomic cation channel activity
- GO:0005272 sodium channel activity
- GO:0044325 transmembrane transporter binding
- GO:0005248 voltage-gated sodium channel activity
- GO:0086002 cardiac muscle cell action potential involved in contraction
- GO:0007231 osmosensory signaling pathway
- GO:0042391 regulation of membrane potential
- GO:0055078 sodium ion homeostasis
- GO:0035725 sodium ion transmembrane transport
Drugs targeting this protein · 55
- OXCARBAZEPINE blocker
- CARBAMAZEPINE blocker
- ETHOTOIN blocker
- PRILOCAINE blocker
- MORICIZINE HYDROCHLORIDE blocker
- INDECAINIDE HYDROCHLORIDE blocker
- ORPHENADRINE CITRATE blocker
- LIDOCAINE HYDROCHLORIDE blocker
- QUINIDINE GLUCONATE blocker
- MEPIVACAINE HYDROCHLORIDE blocker
- PROPARACAINE HYDROCHLORIDE blocker
- DYCLONINE HYDROCHLORIDE blocker
- PRILOCAINE HYDROCHLORIDE blocker
- ETIDOCAINE HYDROCHLORIDE blocker
- MEXILETINE HYDROCHLORIDE blocker
- BENOXINATE HYDROCHLORIDE blocker
- HEXYLCAINE HYDROCHLORIDE blocker
- TOCAINIDE HYDROCHLORIDE blocker
- ARTICAINE HYDROCHLORIDE blocker
- PROCAINE HYDROCHLORIDE blocker
- DISOPYRAMIDE PHOSPHATE blocker
- PHENAZOPYRIDINE HYDROCHLORIDE blocker
- ORPHENADRINE HYDROCHLORIDE blocker
- PROPAFENONE HYDROCHLORIDE blocker
- DRONEDARONE HYDROCHLORIDE blocker
- RUFINAMIDE blocker
- TETRACAINE HYDROCHLORIDE blocker
- PHENYTOIN blocker
- PHENYTOIN SODIUM blocker
- PROPOXYCAINE HYDROCHLORIDE blocker
- ROPIVACAINE HYDROCHLORIDE blocker
- ENCAINIDE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- RALFINAMIDE blocker
- TOPIRAMATE blocker
- IRAMPANEL blocker
- ESLICARBAZEPINE blocker
- DICHLOROBENZYL ALCOHOL blocker
- EVENAMIDE blocker
- QUINIDINE SULFATE blocker
- CENOBAMATE inhibitor
- COCAINE HYDROCHLORIDE blocker
- LACOSAMIDE blocker
- PROCAINAMIDE HYDROCHLORIDE blocker
- TETRACAINE blocker
- LAMOTRIGINE blocker
- RILUZOLE blocker
- ZONISAMIDE blocker
- LIDOCAINE blocker
- PRIMIDONE blocker
- MEPHENYTOIN blocker
- ESLICARBAZEPINE ACETATE blocker
- PHENACEMIDE blocker
- FOSPHENYTOIN SODIUM blocker
- CHLOROPROCAINE HYDROCHLORIDE blocker
Related proteins · sequence + function similarity
- Sodium channel protein type 7 subunit alpha 0.95
- Sodium channel protein type 7 subunit alpha 0.94
- Sodium channel protein type 11 subunit alpha 0.90
- Sodium channel protein type 11 subunit alpha 0.89
- Sodium channel protein 0.89
- Sodium channel protein type 11 subunit alpha 0.88
- Sodium channel protein type 4 subunit alpha B 0.88
- Sodium channel protein type 4 subunit alpha B 0.87
- Sodium channel protein 1 brain 0.86
- Sodium channel protein type 4 subunit alpha 0.85
- Sodium channel protein type 10 subunit alpha 0.85
- Sodium channel protein PaFPC1 0.85
Co-cited proteins · studied together in the literature
- Sodium channel regulatory subunit beta-3 1 shared papers
Literature · 5 cited papers
- Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel. Nat. Commun. · 2022
- Sodium channel Nax is a regulator in epithelial sodium homeostasis. Sci. Transl. Med. · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family. Proc. Natl. Acad. Sci. U.S.A. · 1992
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.