Small ribosomal subunit protein uS12

Function

With S4 and S5 plays an important role in translational accuracy.

Classification

Family (Pfam)

PF00164 Ribosom_S12_S23

InterPro

NA-bd_OB-fold, Ribosomal_uS12, Ribosomal_uS12_bact

Functional cluster

Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 10

• 5V93 EM 4.00A
• 7KGB EM 2.70A
• 7MSC EM 2.97A
• 7MSH EM 3.23A
• 7MSM EM 2.79A
• 7MSZ EM 3.10A
• 7MT2 EM 2.76A
• 7MT3 EM 2.80A
• 7MT7 EM 2.71A
• 7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0046677 response to antibiotic
• GO:0006412 translation

Drugs targeting this protein · 4

• CAPREOMYCIN SULFATE inhibitor
• SUTEZOLID inhibitor
• VIOMYCIN SULFATE inhibitor
• PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS7 1 shared papers
• Small ribosomal subunit protein uS12 1 shared papers
• Small ribosomal subunit protein uS12 1 shared papers
• Small ribosomal subunit protein uS12 1 shared papers
• Small ribosomal subunit protein uS12 1 shared papers
• Small ribosomal subunit protein uS12 1 shared papers

Literature · 7 cited papers

• Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998
• Streptomycin resistance in mycobacteria. Antimicrob. Agents Chemother. · 1994
• The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis. Mol. Microbiol. · 1993
• Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot. Mol. Microbiol. · 1993