Small ribosomal subunit protein uS7

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.

Classification

Family (Pfam)

PF00177 Ribosomal_S7

InterPro

Ribosomal_uS7, Ribosomal_uS7_bact_org, Ribosomal_uS7_CS, Ribosomal_uS7_dom, Ribosomal_uS7_dom_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 11

• 5V93 EM 4.00A
• 6JMK X-ray 1.80A
• 7KGB EM 2.70A
• 7MSC EM 2.97A
• 7MSH EM 3.23A
• 7MSM EM 2.79A
• 7MSZ EM 3.10A
• 7MT2 EM 2.76A
• 7MT3 EM 2.80A
• 7MT7 EM 2.71A
• 7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit
• GO:0009274 peptidoglycan-based cell wall
• GO:0005886 plasma membrane
• GO:0005840 ribosome
• GO:0003729 mRNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0006412 translation

Drugs targeting this protein · 4

• CAPREOMYCIN SULFATE inhibitor
• SUTEZOLID inhibitor
• VIOMYCIN SULFATE inhibitor
• PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 0.99
• Small ribosomal subunit protein uS7 0.99
• Small ribosomal subunit protein uS7 0.99
• Small ribosomal subunit protein uS7 0.99
• Small ribosomal subunit protein uS7 0.98
• Small ribosomal subunit protein uS7 0.98

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS12 1 shared papers

Literature · 5 cited papers

• Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998
• The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis. Mol. Microbiol. · 1993