lmmol · Proteins

C-X-C chemokine receptor type 4

UniProt P61073 Organism Homo sapiens Gene CXCR4

Also known as: CXCR4

Function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation (By similarity). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (By similarity). Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (By similarity).

Classification

Family (Pfam)
PF00001 7tm_1, PF12109 CXCR4_N
InterPro
CCR1-9-like, Chemokine_CXCR4_N_dom, Chemokine_rcpt, CXCR4/ACKR2, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 30

A predicted model is available from AlphaFold.

Gene Ontology · 45

Disease associations

Drugs targeting this protein · 7

Neighborhood · nearest proteins

CXCR4CXCR4CXCR4CXCR4CXCL12CXCR4SAOUHSC_00395
Nearest neighbours of C-X-C chemokine receptor type 4: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 58 cited papers

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