C-C chemokine receptor type 5

UniProt P51681 Organism Homo sapiens Gene CCR5, CMKBR5

Also known as: CCR5, CMKBR5

Function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: CCR1-9-like, Chemokine_CCR5, Chemokine_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster: G Protein-Coupled Receptors

Experimental structures · PDB · 25

2L87 NMR
2MZX NMR
2RLL NMR
2RRS NMR
4MBS X-ray 2.71A
5UIW X-ray 2.20A
5YD3 X-ray 1.35A
5YD4 X-ray 1.35A
5YD5 X-ray 1.96A
5YY4 X-ray 1.59A
6AKX X-ray 2.80A
6AKY X-ray 2.80A
… and 13 more

A predicted model is available from AlphaFold.

Gene Ontology · 32

Disease associations

susceptibility to HIV infection MONDO:0004951
West Nile virus, susceptibility to MONDO:0012482
type 1 diabetes mellitus 22 MONDO:0012921

Drugs targeting this protein · 9

PF-232798 inhibitor
APLAVIROC HYDROCHLORIDE antagonist
INCB-9471 antagonist
AZD5672 antagonist
VICRIVIROC MALEATE antagonist
CENICRIVIROC antagonist
MARAVIROC antagonist
BMS-813160 antagonist
PF-04634817 antagonist

Neighborhood · nearest proteins

Nearest neighbours of C-C chemokine receptor type 5: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Envelope glycoprotein gp160 1 shared papers
Protein UL78 1 shared papers
C-C chemokine receptor type 5 1 shared papers
C-C chemokine receptor type 5 1 shared papers
C-C chemokine receptor type 5 1 shared papers
G protein-coupled receptor kinase 2 1 shared papers
C-X-C chemokine receptor type 4 2 shared papers
PRA1 family protein 2 1 shared papers
Protein cornichon homolog 4 1 shared papers
PRA1 family protein 3 1 shared papers
Beta-arrestin-2 1 shared papers
Peptidoglycan recognition protein 1 1 shared papers

Literature · 36 cited papers

Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors. Acta Naturae · 2018
CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. Traffic · 2014
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science · 2013
Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity. Blood · 2012
The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide. J. Mol. Biol. · 2011
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N. Engl. J. Med. · 2008
Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks. Retrovirology · 2006
The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
CCR5 deficiency increases risk of symptomatic West Nile virus infection. J. Exp. Med. · 2006
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. J. Biol. Chem. · 2005
JM4 is a four-transmembrane protein binding to the CCR5 receptor. FEBS Lett. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 24 more in the literature graph

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