Eukaryotic initiation factor 4A-I

UniProt P60842 Organism Homo sapiens Gene DDX2A, EIF4A, EIF4A1 EC 3.6.4.13

Also known as: DDX2A, EIF4A, EIF4A1

Function

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth.

Classification

Family (Pfam): PF00270 DEAD, PF00271 Helicase_C
InterPro: DEAD/DEAH_box_helicase_dom, EIF4A_DEADc, Helicase_ATP-bd, Helicase_C-like, P-loop_NTPase, RNA-helicase_DEAD-box_CS, RNA_helicase_DEAD_Q_motif
Functional cluster: Serine/Threonine Protein Kinases

Experimental structures · PDB · 14

2G9N X-ray 2.25A
2ZU6 X-ray 2.80A
3EIQ X-ray 3.50A
5ZBZ X-ray 1.31A
5ZC9 X-ray 2.00A
6ZMW EM 3.70A
7PPZ X-ray 2.52A
7PQ0 X-ray 3.00A
8HUJ EM 3.76A
8OZ0 EM 3.50A
8XXN EM 3.60A
9AVR X-ray 1.91A
… and 2 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

Neighborhood · nearest proteins

Nearest neighbours of Eukaryotic initiation factor 4A-I: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Programmed cell death protein 4 2 shared papers
Eukaryotic initiation factor 4A-II 3 shared papers
Plakophilin-1 2 shared papers
Programmed cell death protein 4 1 shared papers
Exportin-7-A 1 shared papers
Nonsense-mediated mRNA decay protein 2 1 shared papers
mRNA export factor ICP27 homolog 1 shared papers
Polyadenylate-binding protein-interacting protein 1 2 shared papers
Nucleolar MIF4G domain-containing protein 1 1 shared papers
Polyadenylate-binding protein 1 3 shared papers
RNA-binding protein 4 1 shared papers
Rho GTPase-activating protein 1 1 shared papers

Literature · 28 cited papers

CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice. Nat. Commun. · 2024
N-terminal proteoforms may engage in different protein complexes. Life. Sci Alliance · 2023
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation. J. Cell Sci. · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Comparative structural analysis of human DEAD-box RNA helicases. PLoS ONE · 2010
Plakophilin 1 stimulates translation by promoting eIF4A1 activity. J. Cell Biol. · 2010
Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1. Proc. Natl. Acad. Sci. U.S.A. · 2010
… and 16 more in the literature graph

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