lmmol · Proteins

Tyrosine-protein kinase JAK3

UniProt P52333 Organism Homo sapiens Gene JAK3 EC 2.7.10.2

Also known as: JAK3

Function

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Classification

Family (Pfam)
PF18379 FERM_F1, PF18377 FERM_F2, PF17887 Jak1_Phl, PF07714 PK_Tyr_Ser-Thr, PF21990 SH2_1
InterPro
Band_41_domain, FERM_domain, FERM_F1, FERM_F2, JAK, JAK1-3/TYK2_PHL_dom, Kinase-like_dom_sf, PH-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser-Thr/Tyr_kinase_cat_dom, SH2, SH2_dom_sf, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_non-rcpt_Jak/Tyk2, Tyr_kinase_non-rcpt_Jak3
Functional cluster
Secreted Growth Factors & Cytokines

Experimental structures · PDB · 42

A predicted model is available from AlphaFold.

Gene Ontology · 42

Disease associations

Drugs targeting this protein · 18

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 27 cited papers

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