Tyrosine-protein kinase Srms

Function

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR.

Classification

Family (Pfam)

PF07714 PK_Tyr_Ser-Thr, PF00017 SH2

InterPro

Kinase-like_dom_sf, Non-receptor_tyrosine_kinases, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser-Thr/Tyr_kinase_cat_dom, SH2, SH2_dom_sf, SH3-like_dom_sf, SH3_domain, Tyr_kinase_AS, Tyr_kinase_cat_dom

Functional cluster

Secreted Growth Factors & Cytokines

Gene Ontology · 13

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0005524 ATP binding
• GO:0004715 non-membrane spanning protein tyrosine kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005102 signaling receptor binding
• GO:0030154 cell differentiation
• GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
• GO:0009968 negative regulation of signal transduction
• GO:0038083 peptidyl-tyrosine autophosphorylation
• GO:0018108 peptidyl-tyrosine phosphorylation
• GO:1904263 positive regulation of TORC1 signaling

Drugs targeting this protein · 5

• DASATINIB ANHYDROUS inhibitor
• ILORASERTIB inhibitor
• XL-228 inhibitor
• TG100-801 inhibitor
• ENMD-981693 inhibitor

Related proteins · sequence + function similarity

• Tyrosine-protein kinase Srms 0.96
• Megakaryocyte-associated tyrosine-protein kinase 0.93
• Megakaryocyte-associated tyrosine-protein kinase 0.93
• Protein-tyrosine kinase 6 0.93
• Megakaryocyte-associated tyrosine-protein kinase 0.92
• Protein-tyrosine kinase 6 0.86
• Non-receptor tyrosine-protein kinase TNK1 0.84
• Tyrosine-protein kinase transforming protein SEA 0.83
• Non-receptor tyrosine-protein kinase TNK1 0.83
• Tyrosine-protein kinase FRK 0.81
• Tyrosine-protein kinase transforming protein Fes 0.81
• Tyrosine-protein kinase JAK3 0.81

Co-cited proteins · studied together in the literature

• Docking protein 1 1 shared papers
• KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 shared papers
• Ubiquitin thioesterase OTUB1 1 shared papers
• Vimentin 1 shared papers
• Regulatory-associated protein of mTOR 1 shared papers
• Proto-oncogene tyrosine-protein kinase Src 1 shared papers

Literature · 5 cited papers

• Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor. Cell Death Differ. · 2023
• Phosphoproteomics analysis identifies novel candidate substrates of the non-receptor tyrosine kinase, SRMS. Mol. Cell. Proteomics · 2018
• The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1. FEBS J. · 2013
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001