Protein farnesyltransferase subunit beta

UniProt P49356 Organism Homo sapiens Gene FNTB EC 2.5.1.58

Also known as: FNTB

Function

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

Classification

Family (Pfam): PF00432 Prenyltrans
InterPro: FTB, PGGT1B-like, Prenyltrans, Terpenoid_cyclase/PrenylTrfase
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Experimental structures · PDB · 14

1JCQ X-ray 2.30A
1LD7 X-ray 2.00A
1LD8 X-ray 1.80A
1MZC X-ray 2.00A
1S63 X-ray 1.90A
1SA4 X-ray 2.10A
1TN6 X-ray 1.80A
2F0Y X-ray 2.70A
2H6F X-ray 1.50A
2H6G X-ray 1.85A
2H6H X-ray 1.80A
2H6I X-ray 3.00A
… and 2 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

Drugs targeting this protein · 2

TIPIFARNIB inhibitor
LONAFARNIB inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 8 shared papers
Protein farnesyltransferase subunit beta 3 shared papers
Protein farnesyltransferase subunit beta 1 shared papers
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2 shared papers
Geranylgeranyl transferase type-1 subunit beta 1 shared papers
Geranylgeranyl transferase type-1 subunit beta 1 shared papers
Protein farnesyltransferase subunit beta 1 shared papers
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1 shared papers

Literature · 13 cited papers

Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem. Biol. · 2009
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J. Mol. Biol. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. J. Med. Chem. · 2003
The DNA sequence and analysis of human chromosome 14. Nature · 2003
3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. J. Med. Chem. · 2002
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc. Natl. Acad. Sci. U.S.A. · 2001
Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. Biochemistry · 1993
… and 1 more in the literature graph

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