Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Also known as: FNTA
Function
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Classification
- Family (Pfam)
- PF01239 PPTA
- InterPro
- Prenyl_trans_a
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 14
- 1JCQ X-ray 2.30A
- 1LD7 X-ray 2.00A
- 1LD8 X-ray 1.80A
- 1MZC X-ray 2.00A
- 1S63 X-ray 1.90A
- 1SA4 X-ray 2.10A
- 1TN6 X-ray 1.80A
- 2F0Y X-ray 2.70A
- 2H6F X-ray 1.50A
- 2H6G X-ray 1.85A
- 2H6H X-ray 1.80A
- 2H6I X-ray 3.00A
- … and 2 more
A predicted model is available from AlphaFold.
Gene Ontology · 24
- GO:0005953 CAAX-protein geranylgeranyltransferase complex
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005875 microtubule associated complex
- GO:0005886 plasma membrane
- GO:0005965 protein farnesyltransferase complex
- GO:0010698 acetyltransferase activator activity
- GO:0043014 alpha-tubulin binding
- GO:0004662 CAAX-protein geranylgeranyltransferase activity
- GO:0019899 enzyme binding
- GO:0008017 microtubule binding
- GO:0060090 molecular adaptor activity
- GO:0004660 protein farnesyltransferase activity
- GO:0004661 protein geranylgeranyltransferase activity
- GO:0004663 Rab geranylgeranyltransferase activity
- GO:0030971 receptor tyrosine kinase binding
- GO:0080120 CAAX-box protein maturation
- GO:0007323 peptide pheromone maturation
- GO:0035022 positive regulation of Rac protein signal transduction
- GO:0018343 protein farnesylation
- GO:0018344 protein geranylgeranylation
- GO:0060632 regulation of microtubule-based movement
- GO:0071340 skeletal muscle acetylcholine-gated channel clustering
- GO:0007179 transforming growth factor beta receptor signaling pathway
Drugs targeting this protein · 2
- TIPIFARNIB inhibitor
- LONAFARNIB inhibitor
Related proteins · sequence + function similarity
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 0.98
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 0.98
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 0.97
- Protein prenyltransferase alpha subunit repeat-containing protein 1 0.64
- Cell division cycle protein 16 homolog 0.58
- Cell division cycle protein 16 homolog 0.57
- N-alpha-acetyltransferase 15, NatA auxiliary subunit 0.57
- N-alpha-acetyltransferase 15, NatA auxiliary subunit 0.57
- KIF-binding protein 0.57
- N-alpha-acetyltransferase 15, NatA auxiliary subunit 0.56
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 0.55
- COP9 signalosome complex subunit 1 0.55
Co-cited proteins · studied together in the literature
- Protein farnesyltransferase subunit beta 8 shared papers
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 3 shared papers
- Protein farnesyltransferase subunit beta 3 shared papers
- Protein farnesyltransferase subunit beta 1 shared papers
- Geranylgeranyl transferase type-1 subunit beta 1 shared papers
- Geranylgeranyl transferase type-1 subunit beta 1 shared papers
- Protein farnesyltransferase subunit beta 1 shared papers
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1 shared papers
- Phosphoribosyl pyrophosphate synthase-associated protein 1 1 shared papers
- AN1-type zinc finger protein 1 1 shared papers
- Cofilin-2 1 shared papers
- Calpastatin 1 shared papers
Literature · 21 cited papers
- N-terminal proteoforms may engage in different protein complexes. Life. Sci Alliance · 2023
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
- Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem. Biol. · 2009
- A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
- The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. · 2006
- Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry · 2006
- DNA sequence and analysis of human chromosome 8. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- … and 9 more in the literature graph
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