Melatonin receptor type 1B
Also known as: MTNR1B
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Mel_1A/1B_rcpt, Melatonin_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 5
A predicted model is available from AlphaFold.
Gene Ontology · 19
- GO:0005886 plasma membrane
- GO:0045202 synapse
- GO:0004930 G protein-coupled receptor activity
- GO:0008502 melatonin receptor activity
- GO:0043010 camera-type eye development
- GO:0007268 chemical synaptic transmission
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0042593 glucose homeostasis
- GO:0051481 negative regulation of cytosolic calcium ion concentration
- GO:0046676 negative regulation of insulin secretion
- GO:0043524 negative regulation of neuron apoptotic process
- GO:0010754 negative regulation of receptor guanylyl cyclase signaling pathway
- GO:0051970 negative regulation of transmission of nerve impulse
- GO:0045906 negative regulation of vasoconstriction
- GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
- GO:0051971 positive regulation of transmission of nerve impulse
- GO:0050796 regulation of insulin secretion
- GO:0098908 regulation of neuronal action potential
Drugs targeting this protein · 5
- AGOMELATINE agonist
- RAMELTEON agonist
- TASIMELTEON agonist
- PIROMELATINE agonist
- MELATONIN agonist
Related proteins · sequence + function similarity
- Melatonin receptor type 1B 0.98
- Melatonin receptor type 1B 0.98
- Melatonin receptor type 1A 0.96
- Melatonin receptor type 1C 0.94
- Melatonin receptor type 1A 0.94
- Melatonin receptor type 1A 0.92
- Melatonin receptor type 1A 0.91
- Melatonin receptor type 1A 0.91
- Melatonin receptor type 1B-A 0.91
- Melatonin receptor type 1B-B 0.90
- Melatonin receptor type 1A-A 0.90
- Melatonin receptor type 1C 0.89
Co-cited proteins · studied together in the literature
- Melatonin receptor type 1B 1 shared papers
- G protein-coupled receptor 135 1 shared papers
- G protein-coupled receptor 61 1 shared papers
- G protein-coupled receptor 62 1 shared papers
- Beta-arrestin-1 1 shared papers
- Beta-arrestin-2 1 shared papers
Literature · 5 cited papers
- XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. Nature · 2019
- Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Sci. Rep. · 2017
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls. Neurosci. Lett. · 2000
- Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc. Natl. Acad. Sci. U.S.A. · 1995
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