Melatonin receptor type 1A
Also known as: MTNR1A
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity).
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Mel_1A/1B_rcpt, Melatonin_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 8
- 6ME2 X-ray 2.80A
- 6ME3 X-ray 2.90A
- 6ME4 X-ray 3.20A
- 6ME5 X-ray 3.20A
- 6PS8 X-ray 3.30A
- 7DB6 EM 3.30A
- 7VGY EM 3.10A
- 7VGZ EM 3.30A
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005886 plasma membrane
- GO:0043235 receptor complex
- GO:0004930 G protein-coupled receptor activity
- GO:0042562 hormone binding
- GO:0008502 melatonin receptor activity
- GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- GO:0007623 circadian rhythm
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0007617 mating behavior
Drugs targeting this protein · 5
- AGOMELATINE agonist
- RAMELTEON agonist
- TASIMELTEON agonist
- PIROMELATINE agonist
- MELATONIN agonist
Related proteins · sequence + function similarity
- Melatonin receptor type 1A 0.99
- Melatonin receptor type 1A 0.98
- Melatonin receptor type 1A 0.98
- Melatonin receptor type 1A-A 0.98
- Melatonin receptor type 1A 0.98
- Melatonin receptor type 1C 0.97
- Melatonin receptor type 1B-B 0.97
- Melatonin receptor type 1B 0.94
- Melatonin receptor type 1B 0.94
- Melatonin receptor type 1C 0.94
- Melatonin receptor type 1B 0.94
- Melatonin receptor type 1B 0.94
Co-cited proteins · studied together in the literature
- Melatonin receptor type 1A 1 shared papers
- Melatonin receptor type 1A 1 shared papers
- Melatonin receptor type 1A 1 shared papers
Literature · 4 cited papers
- Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature · 2019
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. Biochem. Biophys. Res. Commun. · 1999
- Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron · 1994
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