Small ribosomal subunit protein uS7

UniProt P48940 Organism Staphylococcus aureus (strain NCTC 8325 / PS 47) Gene SAOUHSC_00528, rpsG

Also known as: SAOUHSC_00528, rpsG

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.

Classification

Family (Pfam): PF00177 Ribosomal_S7
InterPro: Ribosomal_uS7, Ribosomal_uS7_bact_org, Ribosomal_uS7_CS, Ribosomal_uS7_dom, Ribosomal_uS7_dom_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 17

5LI0 EM 3.80A
5ND8 EM 3.70A
5ND9 EM 3.70A
5TCU EM 3.90A
6YEF EM 3.20A
7BGE EM 3.60A
7KWG EM 3.75A
7NHL EM 3.10A
7NHM EM 3.10A
8BH6 EM 3.70A
8BH7 EM 4.23A
8BYV EM 2.89A
… and 5 more

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 1

RETAPAMULIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

RNA-binding protein SAOUHSC_00526 1 shared papers
Small ribosomal subunit protein uS12 1 shared papers
Ribosomal RNA small subunit methyltransferase H 1 shared papers
Phospho-N-acetylmuramoyl-pentapeptide-transferase 1 shared papers

Literature · 1 cited papers

Penicillin-binding protein 1 of Staphylococcus aureus is essential for growth. J. Bacteriol. · 1998

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