Small ribosomal subunit protein uS12

Function

With S4 and S5 plays an important role in translational accuracy.

Classification

Family (Pfam)

PF00164 Ribosom_S12_S23

InterPro

NA-bd_OB-fold, Ribosomal_uS12, Ribosomal_uS12_bact

Functional cluster

Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 17

• 5LI0 EM 3.80A
• 5ND8 EM 3.70A
• 5ND9 EM 3.70A
• 5TCU EM 3.90A
• 6YEF EM 3.20A
• 7BGD EM 3.20A
• 7KWG EM 3.75A
• 7NHL EM 3.10A
• 7NHM EM 3.10A
• 8BYV EM 2.89A
• 8P2F EM 2.44A
• 8P2G EM 2.02A
• … and 5 more

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0006412 translation

Drugs targeting this protein · 1

• RETAPAMULIN inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00
• Small ribosomal subunit protein uS12 1.00

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS7 1 shared papers
• RNA-binding protein SAOUHSC_00526 1 shared papers
• Ribosomal RNA small subunit methyltransferase H 1 shared papers
• Phospho-N-acetylmuramoyl-pentapeptide-transferase 1 shared papers

Literature · 1 cited papers

• Penicillin-binding protein 1 of Staphylococcus aureus is essential for growth. J. Bacteriol. · 1998